Titre : Maladies néonatales

Maladies néonatales : Questions médicales fréquentes

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une infection néonatale ?

Un diagnostic repose sur des examens cliniques et des analyses sanguines.
Infections néonatales Diagnostic médical
#2

Quels tests pour dépister la jaunisse ?

Un test de bilirubine sanguine est utilisé pour évaluer la jaunisse néonatale.
Jaunisse néonatale Bilirubine
#3

Quels signes indiquent une détresse respiratoire ?

Les signes incluent une respiration rapide, des tirages et une cyanose.
Détresse respiratoire Nouveau-né
#4

Comment évaluer le poids à la naissance ?

Le poids est mesuré immédiatement après la naissance pour détecter des anomalies.
Poids à la naissance Évaluation néonatale
#5

Quels examens pour les malformations congénitales ?

L'échographie prénatale et l'examen physique sont cruciaux pour le diagnostic.
Malformations congénitales Échographie

Symptômes 5

#1

Quels sont les symptômes d'une infection néonatale ?

Fièvre, irritabilité, difficulté à se nourrir et respiration rapide.
Infections néonatales Symptômes
#2

Comment reconnaître une hypoglycémie néonatale ?

Les signes incluent tremblements, irritabilité et somnolence excessive.
Hypoglycémie Nouveau-né
#3

Quels symptômes indiquent une maladie cardiaque congénitale ?

Cyanose, fatigue lors de l'alimentation et respiration rapide.
Maladies cardiaques congénitales Symptômes
#4

Quels signes de jaunisse chez le nouveau-né ?

Teint jaune de la peau et des yeux, généralement visible après 24 heures.
Jaunisse néonatale Symptômes
#5

Quels symptômes d'une infection des voies urinaires ?

Irritabilité, pleurs fréquents et difficulté à uriner.
Infections urinaires Nouveau-né

Prévention 5

#1

Comment prévenir les infections néonatales ?

L'hygiène des mains et la vaccination des mères sont essentielles.
Infections néonatales Prévention
#2

Quelles mesures pour éviter l'hypoglycémie ?

Un suivi régulier de la glycémie et une alimentation adéquate sont cruciaux.
Hypoglycémie Prévention
#3

Comment prévenir la jaunisse chez le nouveau-né ?

Un dépistage précoce et une bonne hydratation peuvent aider.
Jaunisse néonatale Prévention
#4

Quelles sont les recommandations pour les soins prénatals ?

Des soins prénatals réguliers et une nutrition adéquate sont recommandés.
Soins prénatals Prévention
#5

Comment éviter les complications lors de l'accouchement ?

Un suivi médical approprié et une préparation à l'accouchement sont essentiels.
Accouchement Complications

Traitements 5

#1

Quel traitement pour la jaunisse néonatale ?

La photothérapie est souvent utilisée pour réduire les niveaux de bilirubine.
Jaunisse néonatale Photothérapie
#2

Comment traiter une infection néonatale ?

Les antibiotiques sont administrés selon le type d'infection identifiée.
Infections néonatales Antibiotiques
#3

Quel est le traitement de l'hypoglycémie ?

L'administration de glucose par voie intraveineuse ou orale est courante.
Hypoglycémie Traitement
#4

Comment gérer une détresse respiratoire ?

L'oxygénothérapie et la ventilation assistée peuvent être nécessaires.
Détresse respiratoire Oxygénothérapie
#5

Quel traitement pour les malformations congénitales ?

Le traitement varie selon la malformation, pouvant inclure chirurgie ou thérapie.
Malformations congénitales Traitement

Complications 5

#1

Quelles complications peuvent survenir avec la jaunisse ?

Des lésions cérébrales peuvent survenir si la jaunisse n'est pas traitée.
Jaunisse néonatale Complications
#2

Quels risques d'infections néonatales non traitées ?

Les infections non traitées peuvent entraîner des septicémies et des décès.
Infections néonatales Complications
#3

Quelles complications de l'hypoglycémie prolongée ?

Des lésions cérébrales et des troubles du développement peuvent survenir.
Hypoglycémie Complications
#4

Quels sont les effets à long terme des malformations congénitales ?

Les malformations peuvent entraîner des handicaps physiques ou mentaux durables.
Malformations congénitales Complications
#5

Quelles complications respiratoires chez les nouveau-nés ?

Les complications incluent le syndrome de détresse respiratoire et l'apnée.
Détresse respiratoire Complications

Facteurs de risque 5

#1

Quels sont les facteurs de risque d'infections néonatales ?

Les naissances prématurées et les accouchements prolongés augmentent le risque.
Infections néonatales Facteurs de risque
#2

Quels facteurs augmentent le risque d'hypoglycémie ?

Les nouveau-nés de mères diabétiques ou prématurés sont plus à risque.
Hypoglycémie Facteurs de risque
#3

Quels facteurs de risque pour les malformations congénitales ?

L'exposition à des toxines et des antécédents familiaux augmentent le risque.
Malformations congénitales Facteurs de risque
#4

Quels sont les facteurs de risque de jaunisse ?

Les nouveau-nés prématurés et ceux avec des antécédents familiaux sont plus à risque.
Jaunisse néonatale Facteurs de risque
#5

Quels facteurs influencent la détresse respiratoire ?

La prématurité et les infections maternelles pendant la grossesse sont des facteurs clés.
Détresse respiratoire Facteurs de risque
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l'hypoglycémie ?\nComment gérer une détresse respiratoire ?\nQuel traitement pour les malformations congénitales ?", "url": "https://questionsmedicales.fr/mesh/D007232#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Maladies néonatales", "description": "Quelles complications peuvent survenir avec la jaunisse ?\nQuels risques d'infections néonatales non traitées ?\nQuelles complications de l'hypoglycémie prolongée ?\nQuels sont les effets à long terme des malformations congénitales ?\nQuelles complications respiratoires chez les nouveau-nés ?", "url": "https://questionsmedicales.fr/mesh/D007232#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Maladies néonatales", "description": "Quels sont les facteurs de risque d'infections néonatales ?\nQuels facteurs augmentent le risque d'hypoglycémie ?\nQuels facteurs de risque pour les malformations congénitales ?\nQuels sont les facteurs de risque de jaunisse ?\nQuels facteurs influencent la détresse respiratoire ?", "url": "https://questionsmedicales.fr/mesh/D007232#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une infection néonatale ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un diagnostic repose sur des examens cliniques et des analyses sanguines." } }, { "@type": "Question", "name": "Quels tests pour dépister la jaunisse ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Un test de bilirubine sanguine est utilisé pour évaluer la jaunisse néonatale." } }, { "@type": "Question", "name": "Quels signes indiquent une détresse respiratoire ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Les signes incluent une respiration rapide, des tirages et une cyanose." } }, { "@type": "Question", "name": "Comment évaluer le poids à la naissance ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Le poids est mesuré immédiatement après la naissance pour détecter des anomalies." } }, { "@type": "Question", "name": "Quels examens pour les malformations congénitales ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'échographie prénatale et l'examen physique sont cruciaux pour le diagnostic." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une infection néonatale ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fièvre, irritabilité, difficulté à se nourrir et respiration rapide." } }, { "@type": "Question", "name": "Comment reconnaître une hypoglycémie néonatale ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Les signes incluent tremblements, irritabilité et somnolence excessive." } }, { "@type": "Question", "name": "Quels symptômes indiquent une maladie cardiaque congénitale ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Cyanose, fatigue lors de l'alimentation et respiration rapide." } }, { "@type": "Question", "name": "Quels signes de jaunisse chez le nouveau-né ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Teint jaune de la peau et des yeux, généralement visible après 24 heures." } }, { "@type": "Question", "name": "Quels symptômes d'une infection des voies urinaires ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Irritabilité, pleurs fréquents et difficulté à uriner." } }, { "@type": "Question", "name": "Comment prévenir les infections néonatales ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "L'hygiène des mains et la vaccination des mères sont essentielles." } }, { "@type": "Question", "name": "Quelles mesures pour éviter l'hypoglycémie ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier de la glycémie et une alimentation adéquate sont cruciaux." } }, { "@type": "Question", "name": "Comment prévenir la jaunisse chez le nouveau-né ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Un dépistage précoce et une bonne hydratation peuvent aider." } }, { "@type": "Question", "name": "Quelles sont les recommandations pour les soins prénatals ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Des soins prénatals réguliers et une nutrition adéquate sont recommandés." } }, { "@type": "Question", "name": "Comment éviter les complications lors de l'accouchement ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi médical approprié et une préparation à l'accouchement sont essentiels." } }, { "@type": "Question", "name": "Quel traitement pour la jaunisse néonatale ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "La photothérapie est souvent utilisée pour réduire les niveaux de bilirubine." } }, { "@type": "Question", "name": "Comment traiter une infection néonatale ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Les antibiotiques sont administrés selon le type d'infection identifiée." } }, { "@type": "Question", "name": "Quel est le traitement de l'hypoglycémie ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "L'administration de glucose par voie intraveineuse ou orale est courante." } }, { "@type": "Question", "name": "Comment gérer une détresse respiratoire ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "L'oxygénothérapie et la ventilation assistée peuvent être nécessaires." } }, { "@type": "Question", "name": "Quel traitement pour les malformations congénitales ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement varie selon la malformation, pouvant inclure chirurgie ou thérapie." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec la jaunisse ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des lésions cérébrales peuvent survenir si la jaunisse n'est pas traitée." } }, { "@type": "Question", "name": "Quels risques d'infections néonatales non traitées ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Les infections non traitées peuvent entraîner des septicémies et des décès." } }, { "@type": "Question", "name": "Quelles complications de l'hypoglycémie prolongée ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des lésions cérébrales et des troubles du développement peuvent survenir." } }, { "@type": "Question", "name": "Quels sont les effets à long terme des malformations congénitales ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Les malformations peuvent entraîner des handicaps physiques ou mentaux durables." } }, { "@type": "Question", "name": "Quelles complications respiratoires chez les nouveau-nés ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent le syndrome de détresse respiratoire et l'apnée." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque d'infections néonatales ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les naissances prématurées et les accouchements prolongés augmentent le risque." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque d'hypoglycémie ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Les nouveau-nés de mères diabétiques ou prématurés sont plus à risque." } }, { "@type": "Question", "name": "Quels facteurs de risque pour les malformations congénitales ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "L'exposition à des toxines et des antécédents familiaux augmentent le risque." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de jaunisse ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Les nouveau-nés prématurés et ceux avec des antécédents familiaux sont plus à risque." } }, { "@type": "Question", "name": "Quels facteurs influencent la détresse respiratoire ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "La prématurité et les infections maternelles pendant la grossesse sont des facteurs clés." } } ] } ] }
Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 09/04/2026

Contenu vérifié selon les dernières recommandations médicales

Sous-catégories

26 au total
└─

Maladie des brides amniotiques

Amniotic Band Syndrome D000652 - C16.614.042
└─

Anémie néonatale

Anemia, Neonatal D000751 - C16.614.053
└─

Asphyxie néonatale

Asphyxia Neonatorum D001238 - C16.614.092
└─

Colique

Colic D003085 - C16.614.166
└─

Insuffisances médullaires congénitales

Congenital Bone Marrow Failure Syndromes D000080984 - C16.614.183
└─

Mucoviscidose

Cystic Fibrosis D003550 - C16.614.213
└─

Épilepsie bénigne néonatale

Epilepsy, Benign Neonatal D020936 - C16.614.258
└─

Hydrophtalmie

Hydrophthalmos D006871 - C16.614.438
└─

Hyperostose corticale infantile

Hyperostosis, Cortical, Congenital D006958 - C16.614.465
└─

Maladies du prématuré

Infant, Premature, Diseases D007235 - C16.614.521
└─

Syndrome d'aspiration méconiale

Meconium Aspiration Syndrome D008471 - C16.614.580
└─

Syndrome de Moebius

Mobius Syndrome D020331 - C16.614.595
└─

Nystagmus congénital

Nystagmus, Congenital D020417 - C16.614.643
└─

Conjonctivite du nouveau-né

Ophthalmia Neonatorum D009878 - C16.614.677
└─

Persistance de la circulation foetale

Persistent Fetal Circulation Syndrome D010547 - C16.614.694
└─

Syphilis congénitale

Syphilis, Congenital D013590 - C16.614.868
└─

Dysplasie thanatophore

Thanatophoric Dysplasia D013796 - C16.614.890
└─

Thrombocytopénie néonatale allo-immune

Thrombocytopenia, Neonatal Alloimmune D054098 - C16.614.899
└─

Toxoplasmose congénitale

Toxoplasmosis, Congenital D014125 - C16.614.909
└─└─

Syndrome de transfusion foeto-foetale

Fetofetal Transfusion D005330 - C16.614.053.344
└─└─

Transfusion foetomaternelle

Fetomaternal Transfusion D005331 - C16.614.053.511
└─└─

Dysplasie bronchopulmonaire

Bronchopulmonary Dysplasia D001997 - C16.614.521.125
└─└─

Leucomalacie périventriculaire

Leukomalacia, Periventricular D007969 - C16.614.521.450
└─└─

Syndrome de détresse respiratoire du nouveau-né

Respiratory Distress Syndrome, Newborn D012127 - C16.614.521.563
└─└─

Rétinopathie du prématuré

Retinopathy of Prematurity D012178 - C16.614.521.731
└─└─└─

Maladie des membranes hyalines

Hyaline Membrane Disease D006819 - C16.614.521.563.475

Auteurs principaux

Matteo Bruschettini

3 publications dans cette catégorie

Affiliations :
  • Paediatrics, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
  • Cochrane Sweden, Department of Research and Education, Lund University, Skåne University Hospital, Lund, Sweden.
Publications dans "Maladies néonatales" :

Olga Romantsik

3 publications dans cette catégorie

Affiliations :
  • Department of Clinical Sciences Lund, Paediatrics, Lund University, Skåne University Hospital, Lund, Sweden.
Publications dans "Maladies néonatales" :

Kanwaljeet J S Anand

2 publications dans cette catégorie

Affiliations :
  • From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.

Sara Pessano

2 publications dans cette catégorie

Affiliations :
  • Neonatal Intensive Care Unit, Department Mother and Child, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Publications dans "Maladies néonatales" :

Marcus Glenton Prescott

2 publications dans cette catégorie

Affiliations :
  • Clinic of Emergency Medicine and Prehospital Care, St. Olav's Hospital-Trondheim University Hospital, Trondheim, Norway.
Publications dans "Maladies néonatales" :

Angelika Zankl

2 publications dans cette catégorie

Affiliations :
  • Department of Neonatal Medicine, RPA Women and Babies, Royal Prince Alfred Hospital, Camperdown, Australia.
  • Central Clinical School, School of Medicine, The University of Sydney, Sydney, Australia.
Publications dans "Maladies néonatales" :

Jill Martin

2 publications dans cette catégorie

Affiliations :
  • Department of Neonatal Medicine, RPA Women and Babies, Royal Prince Alfred Hospital, Camperdown, Australia.
Publications dans "Maladies néonatales" :

Jane G Davey

2 publications dans cette catégorie

Affiliations :
  • Department of Neonatal Medicine, RPA Women and Babies, Royal Prince Alfred Hospital, Camperdown, Australia.
Publications dans "Maladies néonatales" :

David A Osborn

2 publications dans cette catégorie

Affiliations :
  • Department of Neonatal Medicine, RPA Women and Babies, Royal Prince Alfred Hospital, Camperdown, Australia.
  • Central Clinical School, School of Medicine, The University of Sydney, Sydney, Australia.
Publications dans "Maladies néonatales" :

Charles C Roehr

2 publications dans cette catégorie

Affiliations :
  • National Perinatal Epidemiology Unit, Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.
  • Newborn Services, Southmead Hospital, North Bristol Trust, Bristol, UK.
  • Faculty of Health Sciences, University of Bristol, Bristol, UK.
Publications dans "Maladies néonatales" :

None None

2 publications dans cette catégorie

Publications dans "Maladies néonatales" :

Georg M Schmölzer

2 publications dans cette catégorie

Affiliations :
  • Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada georg.schmoelzer@me.com.
Publications dans "Maladies néonatales" :

Domenico Umberto De Rose

2 publications dans cette catégorie

Affiliations :
  • Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.
  • PhD Course in Microbiology, Immunology, Infectious Diseases, and Transplants (MIMIT), Faculty of Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.

Anna Claudia Massolo

2 publications dans cette catégorie

Affiliations :
  • Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Human Milk Bank, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.

Neil Patel

2 publications dans cette catégorie

Affiliations :
  • Department of Neonatology, Royal Hospital for Children, Glasgow G51 4TF, UK.

Irma Capolupo

2 publications dans cette catégorie

Affiliations :
  • Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Human Milk Bank, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.

Alessandra Toscano

2 publications dans cette catégorie

Affiliations :
  • Perinatal Cardiology Unit, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.

Andrea Dotta

2 publications dans cette catégorie

Affiliations :
  • Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Human Milk Bank, Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital, IRCCS, 00165 Rome, Italy.

Fiammetta Piersigilli

2 publications dans cette catégorie

Affiliations :
  • Neonatal Intensive Care Unit, Department of Neonatology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.
  • Division of Neonatology, St-Luc University Hospital, Catholic University of Louvain, 1200, Brussels, Belgium.
Publications dans "Maladies néonatales" :

László Rovó

2 publications dans cette catégorie

Affiliations :
  • Department of Otorhinolaryngology and Head & Neck Surgery, University of Szeged, Szeged, Hungary.

Sources (10000 au total)

Newborn genetic screening is highly effective for high-risk infants: A single-centre study in China.

Newborn genetic screening (NBGS) is promising for early detection of genetic diseases in newborns. However, little is known about its clinical effectiveness in special groups like high-risk infants. T... We screened 10 334 healthy newborns from the general maternity unit and 886 high-risk infants from the neonatal ward using both traditional newborn screening (tNBS) and NBGS, and collected clinical da... We found that high-risk infants had a higher proportion of eutocia (P < 0.01) and prematurity (P < 0.01). For high-risk infants vs healthy newborns screened by tNBS, the primary screening positive rat... We found that combined newborn screening can effectively reduce the FPR caused by the high-risk symptoms and improve the PPV in high-risk infants, sufficient for more accurately showing the true statu...

Impact of postpartum maternal fever or hypothermia on newborn and early infant illness and death in Southwestern Uganda.

Deaths occurring during the neonatal period contribute close to half of under-five mortality rate (U5MR); over 80% of these deaths occur in low- and middle-income countries (LMICs). Poor maternal ante... The objective of the study was to assess the association between abnormal postpartum maternal temperature and early infant outcomes, specifically illness requiring hospitalisation or leading to death ... Of the 648 postpartum participants from the parent study who agreed to enrol their neonates in the sub-study, 100 (15%) mothers had abnormal temperature. The mean maternal age was 24.6 (SD 5.3) years,... While our results do not demonstrate an association between abnormal maternal temperature and newborn and early infant outcomes, good routine neonate care should be emphasized, and the infants should ... BMC Pregnancy and Childbirth ( https://bmcpregnancychildbirth.biomedcentral.com/ )....

Neonatal Risk Factors for Growth Retardation in Infants With Congenital Heart Disease.

While the association of congenital heart disease (CHD) and growth retardation (GR) is known, data remain limited. This study investigated the incidence of GR and its neonatal risk factors in patients... The study population was extracted from Korean National Health Insurance Service claims data from January 2002 to December 2020. We included patients diagnosed with CHD under one year of age. GR was d... The number of patients diagnosed with CHD within the first year of birth was 133,739. Of these, 2,921 newborns were diagnosed with GR. The cumulative incidence of GR was 4.8% at 19 years of age for in... Several neonatal conditions were significant risk factors for GR in CHD patients, and appropriate monitoring and treatment programs are required in CHD neonates with these factors. Considering this st...

High Throughput Newborn Screening for Sickle Cell Disease - Application of Two-Tiered Testing with a qPCR-Based Primary screen.

Sickle cell disease (SCD) is a group of hemoglobinopathies with a common point mutation causing the production of sickle cell hemoglobin (HbS). In high-throughput newborn screening (NBS) for SCD, a tw... Three NBS centers using qPCR-based primary screening for SCD performed a laboratory comparison. Methods using tandem MS or HPLC were used for differentiation.... In a benchmarking test, 450 dried blood samples were analyzed. Samples containing HbS were detected as reliably by qPCR as by methods established for hemoglobinopathy testing. In a two-step screening ... In high-throughput NBS for SCD, qPCR is suitable to focus 2...

Establishment of a nomogram model for predicting metabolic bone disease in preterm infants: A case‒control study.

To investigate risk factors for metabolic bone disease (MBD) in preterm infants and establish a nomogram model for predicting MBD risk.... A total of 1104 preterm infants were enrolled, among whom 809 were included in the modelling set and 295 were included in the validation set. The modelling set was divided into MBD (n = 185) and non-M... Gestational age, time of trophic feeding initiation, parenteral nutrition duration, necrotizing enterocolitis, bronchopulmonary dysplasia, cholestasis and sepsis were independent risk factors for MBD ... The nomogram model provides an efficient tool for the early assessment of MBD risk. Preterm infants with scores ≥ 125 should receive close attention and interventions in the early stage.... • The incidence and severity of MBD are inversely proportional to gestational age and birth weight. Bone loss can lead to prolonged hospital stay, ventilator dependence, pathological fractures and sho... • Gestational age, time of trophic feeding initiation, parenteral nutrition duration, necrotizing enterocolitis, bronchopulmonary dysplasia, cholestasis and sepsis were independent risk factors for MB...

Maternal Characteristics and Rates of Unexpected Complications in Term Newborns by Hospital.

The Joint Commission Unexpected Complications in Term Newborns measure characterizes newborn morbidity potentially associated with quality of labor and delivery care. Infant exclusions isolate relativ... To investigate the association between maternal characteristics and hospital UNC rates.... This cohort study was conducted using linked 2016 to 2018 New York City birth and hospital discharge datasets among 254 259 neonates at low risk (singleton, ≥37 weeks, birthweight ≥2500 g, and without... UNCs were classified according to Joint Commission International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) criteria. Maternal preadmission comorbiditi... Among 254 259 singleton births at 37 weeks or later who were at low risk (125 245 female [49.3%] and 129 014 male [50.7%]; 71 768 births [28.2%] to Hispanic, 47 226 births [18.7%] to non-Hispanic Asia... In this study, adjustment for maternal case mix was associated with small overall changes in hospital UNC rates. These changes were associated with performance assessment for some hospitals, and these...

Prevalence of macrosomic newborn and maternal and neonatal complications in a high-risk maternity.

Evaluate the prevalence of macrosomic newborns (birth weight above 4000 grams) in a high-risk maternity from 2014 to 2019, as well as the maternal characteristics involved, risk factors, mode of deliv... This is an observational study, case-control type, carried out by searching for data in hospital's own system and clinical records. The criteria for inclusion in the study were all patients monitored ... From 2014 to 2019, 3.3% of deliveries were macrosomic newborns. The average gestational age in the birth was 39.4 weeks. The most common mode of delivery (65%) was cesarean section. Diabetes mellitus ... Birth weight above 4000 grams had a statistically significant impact on the occurrence of neonatal complications, such as hypoglycemia, respiratory distress and 5th minute APGAR less than 7, especiall...

Reduction in regulatory T cells in preterm newborns is associated with necrotizing enterocolitis.

Despite multifactorial pathogenesis, dysregulation of inflammatory immune response may play a crucial role in necrotizing enterocolitis (NEC). Regulatory T cells (Tregs) are involved in immune toleran... We studied six newborns with a diagnosis of NEC (cases) in comparison with 52 controls (without NEC). We further classified controls as neonates with feeding intolerance (FI) and neonates without it (... We observed, at T0, a significantly lower frequency of Tregs in NEC cases (p < 0.001) compared with both FI (p < 0.01) and FeedTol controls (p < 0.01). Multivariate analysis reported that the occurren... Tregs frequency and features in the peripheral blood of preterm neonates, early in life, may contribute to identifying neonates at high risk of developing NEC.... Regulatory T cells may play a pivotal role in regulating the immune response in early life. Reduction of Tregs in early life could predispose preterm newborns to necrotizing enterocolitis. Early marke...

Placental Pathology and Its Importance in Preterm Infants.

We evaluated what placental pathologies were associated with adverse preterm births.... Placental findings, classified according to the Amsterdam criteria, were correlated with infant outcomes. The fetal vascular lesions, inflammatory responses other than histological chorioamnionitis (H... A total of 772 placentas were evaluated. MVM was present in 394 placentas, HCA in 378. Early neonatal sepsis, retinopathy of prematurity, necrotizing enterocolitis, and neonatal death occurred more of... Inflammation in the placenta influences fetal and neonatal outcomes. HCA is an independent risk factor for BPD....