A review of the influence of functional group modifications to the core scaffold of synthetic cathinones on drug pharmacokinetics.
Bath salts
Pharmacokinetics
Review
Synthetic cathinones
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
21
05
2018
accepted:
23
07
2018
pubmed:
3
8
2018
medline:
28
10
2019
entrez:
3
8
2018
Statut:
ppublish
Résumé
The synthetic cathinones are a class of designer drugs of abuse that share a common core scaffold. The pharmacokinetic profiles of the synthetic cathinones vary based on the substitutions to the core scaffold. To provide a summary of the literature regarding the pharmacokinetic characteristics of the synthetic cathinones, with a focus on the impact of the structural modifications to the pharmacokinetics. In many, but not all, instances the pharmacokinetic characteristics of the synthetic cathinones can be reasonably predicted based on the substitutions to the core scaffold. Mephedrone and methylone are chemically alike and have similar T Continued research will lead to a better understanding of the pharmacokinetic changes associated with structural modifications to the cathinone scaffold, and potentially in the long range, enhanced overdose and addiction therapy. Additionally, the areas of polydrug use and pharmacogenetics have been largely overlooked with regard to synthetic cathinones.
Identifiants
pubmed: 30069588
doi: 10.1007/s00213-018-4985-6
pii: 10.1007/s00213-018-4985-6
doi:
Substances chimiques
Alkaloids
0
Amphetamines
0
Designer Drugs
0
Synthetic Drugs
0
Methamphetamine
44RAL3456C
cathinone
540EI4406J
mephedrone
8BA8T27317
pentylone
IGN39WGH0Q
methylone
L4I4B1R01F
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
881-890Références
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