BK polyomavirus in the urine for follow-up of kidney transplant recipients.
Adult
BK Virus
/ isolation & purification
DNA, Viral
/ urine
Follow-Up Studies
Humans
Kidney Diseases
/ blood
Kidney Transplantation
/ adverse effects
Polyomavirus Infections
/ blood
Prospective Studies
Real-Time Polymerase Chain Reaction
Retrospective Studies
Sensitivity and Specificity
Transplant Recipients
Urine
/ virology
Viremia
BK virus
BKPyV viraemia
BKPyV viruria
Kidney transplantation
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
27
03
2018
revised:
22
07
2018
accepted:
24
07
2018
pubmed:
5
8
2018
medline:
26
4
2019
entrez:
5
8
2018
Statut:
ppublish
Résumé
After kidney transplantation, human BK polyomavirus (BKPyV) can induce a progressive disease, in three stages: viruria, viraemia, and then nephropathy after a few months of viral replication. Therapeutic intervention is recommended when BKPyV is detected in the plasma. The objective of our study was to assess urinary BKPyV nucleic acid test as a predictor for developing viraemia. We first defined a viruria threshold based on 393 time-matched urine and plasma samples collected after kidney transplantation; to validate this threshold, we followed-up a cohort of 236 kidney transplant patients. A BKPyV viruria threshold of 6.71 log Sustained BKPyV viruria is a reliable, early marker of patients at high risk of developing BKPyV viraemia. This marker should alert the clinician early, and thus allow timely therapeutic intervention.
Identifiants
pubmed: 30076973
pii: S1198-743X(18)30545-7
doi: 10.1016/j.cmi.2018.07.027
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112.e1-112.e5Informations de copyright
Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.