Current understanding of thalamic structure and function in migraine.
Analgesics
/ pharmacology
Brain Mapping
Central Nervous System Sensitization
/ physiology
Cerebral Cortex
/ physiopathology
Connectome
Emotions
/ physiology
Humans
Hyperalgesia
/ etiology
Magnetic Resonance Imaging
Migraine Disorders
/ complications
Neural Pathways
/ physiopathology
Nociception
/ physiology
Organ Size
Pain Perception
/ physiology
Photophobia
/ etiology
Positron-Emission Tomography
Proton Magnetic Resonance Spectroscopy
Thalamic Nuclei
/ physiopathology
Thalamus
/ diagnostic imaging
Tomography, X-Ray Computed
Migraine
allodynia
functional connectivity
pain processing
photophobia
sensitization
thalamus
Journal
Cephalalgia : an international journal of headache
ISSN: 1468-2982
Titre abrégé: Cephalalgia
Pays: England
ID NLM: 8200710
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
7
8
2018
medline:
21
10
2020
entrez:
7
8
2018
Statut:
ppublish
Résumé
To review and discuss the literature on the role of thalamic structure and function in migraine. The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.
Identifiants
pubmed: 30079744
doi: 10.1177/0333102418791595
pmc: PMC7583318
mid: NIHMS1636466
doi:
Substances chimiques
Analgesics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1675-1682Subventions
Organisme : NINDS NIH HHS
ID : R01 NS104296
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS090254
Pays : United States
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