Sildenafil Exposure in the Neonatal Intensive Care Unit.
Bronchopulmonary Dysplasia
/ etiology
Drug Utilization
/ trends
Female
Humans
Hypertension, Pulmonary
/ complications
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
/ drug therapy
Intensive Care Units, Neonatal
Male
Meconium Aspiration Syndrome
Retrospective Studies
Sildenafil Citrate
/ adverse effects
Vasodilator Agents
/ adverse effects
Journal
American journal of perinatology
ISSN: 1098-8785
Titre abrégé: Am J Perinatol
Pays: United States
ID NLM: 8405212
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
7
8
2018
medline:
18
4
2020
entrez:
7
8
2018
Statut:
ppublish
Résumé
Pulmonary hypertension causes substantial morbidity and mortality in infants. Although Food and Drug Administration approved to treat pulmonary arterial hypertension in adults, sildenafil is not approved for infants. We sought to describe sildenafil exposure and associated diagnoses and outcomes in infants. Retrospective cohort of neonates discharged from more than 300 neonatal intensive care units from 2001 to 2016. Sildenafil was administered to 1,336/1,161,808 infants (0.11%; 1.1 per 1,000 infants); 0/35,977 received sildenafil in 2001 versus 151/90,544 (0.17%; 1.7 per 1,000 infants) in 2016. Among infants <32 weeks' gestational age (GA) with enough data to determine respiratory outcome, 666/704 (95%) had bronchopulmonary dysplasia (BPD). Among infants ≥32 weeks GA, 248/455 (55%) had BPD and 76/552 (14%) were diagnosed with meconium aspiration. Overall, 209/921 (23%) died prior to discharge. The use of sildenafil has increased since 2001. Exposed infants were commonly diagnosed with BPD. Further studies evaluating dosing, safety, and efficacy of sildenafil are needed.
Identifiants
pubmed: 30081404
doi: 10.1055/s-0038-1667378
pmc: PMC6996478
mid: NIHMS1068741
doi:
Substances chimiques
Vasodilator Agents
0
Sildenafil Citrate
BW9B0ZE037
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-267Subventions
Organisme : NICHD NIH HHS
ID : HHSN275201000001Z
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN267200700051C
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081044
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD068497
Pays : United States
Organisme : NHLBI NIH HHS
ID : R34 HL124038
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275201000003I
Pays : United States
Organisme : FDA HHS
ID : R18 FD005292
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001117
Pays : United States
Organisme : NIAAA NIH HHS
ID : HHSN275201000003C
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275201000001G
Pays : United States
Informations de copyright
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Déclaration de conflit d'intérêts
None.
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