Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.

Anorexia Nervosa / genetics Body Mass Index Comorbidity Genome-Wide Association Study Humans Obsessive-Compulsive Disorder / genetics Phenotype

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
09 2020
Historique:
received: 11 12 2017
accepted: 25 05 2018
revised: 16 03 2018
pubmed: 9 8 2018
medline: 15 5 2021
entrez: 9 8 2018
Statut: ppublish

Résumé

Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-analysis of 3495 AN cases, 2688 OCD cases, and 18,013 controls. We confirmed a high genetic correlation between AN and OCD (r

Identifiants

DOI: 10.1038/s41380-018-0115-4 PMID: 30087453 PMC: PMC6367065
pubmed: 30087453
doi: 10.1038/s41380-018-0115-4
pii: 10.1038/s41380-018-0115-4
pmc: PMC6367065
mid: NIHMS970893
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2036-2046

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH071507
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079488
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079489
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079494
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH076694
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124871
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110427
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079487
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH109782
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105500
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109539
Pays : United States

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Auteurs

Zeynep Yilmaz (Z)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-8145-1596

Matthew Halvorsen (M)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Julien Bryois (J)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-4747-2166

Dongmei Yu (D)

Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Laura M Thornton (LM)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Stephanie Zerwas (S)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nadia Micali (N)

Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
UCL Institute of Child Health, UCL, London, UK.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Rainald Moessner (R)

Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany.

Christie L Burton (CL)

Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
ORCID: 0000-0002-8955-6528

Gwyneth Zai (G)

Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Lauren Erdman (L)

Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.

Martien J Kas (MJ)

Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Paul D Arnold (PD)

Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Mathison Centre for Mental Health Research & Education, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Lea K Davis (LK)

Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0001-5143-2282

James A Knowles (JA)

SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.

Gerome Breen (G)

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Jeremiah M Scharf (JM)

Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Gerald Nestadt (G)

Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA.

Carol A Mathews (CA)

Department of Psychiatry, Genetics Institute, University of Florida, Gainesville, FL, USA.

Cynthia M Bulik (CM)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Manuel Mattheisen (M)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.
The Lundbeck Foundation Initiative of Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

James J Crowley (JJ)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. crowley@unc.edu.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. crowley@unc.edu.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. crowley@unc.edu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Anorexie mentale › Examination of the shared genetic basis of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Examination of the shared genetic basis of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Examination of the shared genetic basis of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Examination of the shared genetic basis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Examination of the shared genetic basis of...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Examination of the shared genetic basis of...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Examination of the shared genetic basis of...