Limited benefit of slow rewarming after cerebral hypothermia for global cerebral ischemia in near-term fetal sheep.
Encephalopathy
fetus
hypothermia
hypoxia-ischemia
rewarming
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
11
8
2018
medline:
17
6
2020
entrez:
11
8
2018
Statut:
ppublish
Résumé
The optimal rate of rewarming after therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy is unknown, although it is widely suggested that slow rewarming is beneficial. Some preclinical studies suggest better outcomes with slower rewarming, but did not control for the duration of hypothermia. In this study, near-term fetal sheep (0.85 gestation) received 30 min cerebral ischemia followed by normothermia, 48 h hypothermia with rapid rewarming over 1 h, 48-h hypothermia with slow rewarming over 24 h, or 72-h hypothermia with rapid rewarming. Slow rewarming after 48 h of hypothermia improved recovery of EEG power compared with rapid rewarming (
Identifiants
pubmed: 30092709
doi: 10.1177/0271678X18791631
pmc: PMC6827112
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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