The application of stable-isotope tracers to study human musculoskeletal protein turnover: a tale of bag filling and bag enlargement.
Breakdown
Collagen synthesis
Insulin
Nutrition
Protein Turnover
Skeletal muscle
Stable isotopes
Synthesis
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
16
04
2018
accepted:
09
07
2018
pubmed:
12
8
2018
medline:
8
7
2020
entrez:
12
8
2018
Statut:
ppublish
Résumé
The nutritional regulation of protein and amino acid balance in human skeletal muscle carried out by the authors with Mike Rennie is reviewed in the context of a simple physiological model for the regulation of the maintenance and growth of skeletal muscle, the "Bag Theory". Beginning in London in the late 1970s the work has involved the use of stable isotopes to probe muscle protein synthesis and breakdown with two basic experimental models, primed-dose continuous tracer infusions combined with muscle biopsies and arterio-venous (A-V) studies across a limb, most often the leg, allowing both protein synthesis and breakdown as well as net balance to be measured. In this way, over a 30 year period, the way in which amino acids and insulin mediate the anabolic effect of a meal has been elaborated in great detail confirming the original concepts of bag filling within the muscle endomysial "bag", which is limited by the "bag" size unless bag enlargement occurs requiring new collagen synthesis. Finally we briefly review some new developments involving
Identifiants
pubmed: 30097998
doi: 10.1113/JP275430
pmc: PMC6395420
doi:
Substances chimiques
Isotopes
0
Muscle Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1235-1249Subventions
Organisme : Medical Research Council
ID : MR/P021220/1
Pays : United Kingdom
Informations de copyright
© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.
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