Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty.
Age Factors
Aged
Analgesics, Opioid
/ administration & dosage
Arthroplasty, Replacement, Hip
/ adverse effects
Arthroplasty, Replacement, Knee
/ adverse effects
Female
Health Status Indicators
Humans
Injections, Spinal
Male
Middle Aged
Morphine
/ administration & dosage
Pain, Postoperative
/ drug therapy
Postoperative Nausea and Vomiting
/ chemically induced
Pruritus
/ chemically induced
Respiratory Insufficiency
/ chemically induced
Retrospective Studies
Sex Factors
Time Factors
Anesthesia
Arthroplasty
Hip
Intrathecal morphine
Knee
Neuraxial
Spinal
Journal
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
ISSN: 1432-1068
Titre abrégé: Eur J Orthop Surg Traumatol
Pays: France
ID NLM: 9518037
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
05
06
2018
accepted:
03
08
2018
pubmed:
15
8
2018
medline:
3
5
2019
entrez:
15
8
2018
Statut:
ppublish
Résumé
Intrathecal morphine (ITM) can be useful for postoperative analgesia following lower extremity joint arthroplasty, but concerns exist regarding potential dose-related side effects. In this study, we examined the safety and efficacy of ITM in patients undergoing lower extremity joint arthroplasty. We hypothesized that there would be (1) direct relationship between dosing and side effects, and (2) an inverse relationship between ITM dosing and 24-hour postoperative opioid requirement.
Identifiants
pubmed: 30105593
doi: 10.1007/s00590-018-2293-9
pii: 10.1007/s00590-018-2293-9
doi:
Substances chimiques
Analgesics, Opioid
0
Morphine
76I7G6D29C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-129Subventions
Organisme : National Institutes of Health
ID : UL1TR000058
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