Clinical Significance of Sarcopenia among Patients with Advanced Oropharyngeal Cancer.
Aged
Body Mass Index
Carcinoma, Squamous Cell
/ complications
Disease-Free Survival
Female
Humans
Male
Middle Aged
Oropharyngeal Neoplasms
/ complications
Papillomavirus Infections
/ complications
Positron Emission Tomography Computed Tomography
Prevalence
Retrospective Studies
Sarcopenia
/ diagnosis
Survival Rate
head and neck cancer
human papillomavirus
oropharyngeal squamous cell carcinoma
sarcopenia
Journal
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
ISSN: 1097-6817
Titre abrégé: Otolaryngol Head Neck Surg
Pays: England
ID NLM: 8508176
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
15
8
2018
medline:
28
11
2019
entrez:
15
8
2018
Statut:
ppublish
Résumé
We investigated the prevalence and impact of sarcopenia on disease-free survival (DFS) and overall survival (OS) in advanced oropharyngeal cancer. Retrospective study. Single-institution tertiary cancer care center. We identified patients with advanced oropharyngeal cancer with pretreatment positron emission tomography-computed tomography scans for image analysis. Data were collected on the following variables: age, sex, smoking and alcohol status, stage (TNM and American Joint Committee on Cancer), human papillomavirus (HPV) status, body mass index (BMI), and treatment modality. Of 113 patients identified with oropharyngeal cancer, 32 had sarcopenia: these patients were older (63.5 vs 57.6 years, P = .01), were less likely to be male (53.1% vs 76.5%, P = .03), and had a lower mean BMI (24.5 vs 28.4 kg/m Sarcopenia is a prognostic factor affecting OS independent of HPV status in advanced oropharyngeal cancer.
Identifiants
pubmed: 30105922
doi: 10.1177/0194599818793857
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM