Mesenchymal Stem Cells, Immune Cells and Tumor Cells Crosstalk: A Sinister Triangle in the Tumor Microenvironment.
Mesenchymal stem cells
adaptive immune
response
immunomodulation
innate immune response
metastasis
tumor microenvironment.
Journal
Current stem cell research & therapy
ISSN: 2212-3946
Titre abrégé: Curr Stem Cell Res Ther
Pays: United Arab Emirates
ID NLM: 101272517
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
04
2018
revised:
08
08
2018
accepted:
09
08
2018
pubmed:
17
8
2018
medline:
30
4
2019
entrez:
17
8
2018
Statut:
ppublish
Résumé
Mesenchymal Stem Cells [MSCs] are a heterogeneous population of fibroblast-like cells which maintain self-renewability and pluripotency. Many studies have demonstrated the immunomodulatory effects of MSCs on the innate and adaptive immune cells. As a result of interactions with tumor cells, microenvironment and immune-stimulating milieu, MSCs contribute to tumor progression by several mechanisms, including sustained proliferative signal in cancer stem cells [CSCs], inhibition of tumor cell apoptosis, transition to tumor-associated fibroblasts [TAFs], promotion of angiogenesis, stimulation of epithelial-mesenchymal transition [EMT], suppression of immune responses, and consequential promotion of tumor metastasis. Here, we present an overview of the latest findings on Janusfaced roles that MSCs play in the tumor microenvironment [TME], with a concise focus on innate and adaptive immune responses.
Identifiants
pubmed: 30112998
pii: CSCR-EPUB-92428
doi: 10.2174/1574888X13666180816114809
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-51Informations de copyright
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