Pathogens and autoimmune hepatitis.
CYP2D6
Inflammation
autoimmunity
molecular mimicry
virus infection
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
05
2018
revised:
30
07
2018
accepted:
06
08
2018
pubmed:
17
8
2018
medline:
29
10
2019
entrez:
17
8
2018
Statut:
ppublish
Résumé
Autoimmune hepatitis (AIH) is a severe form of hepatitis resulting in the autoimmune-mediated destruction of the liver parenchyma. Whereas many of the immunopathogenic events have been elucidated and some of the drivers of the disease have been identified, little is known about the aetiology of the disease. There are certain risk factors, such as particular human leucocyte antigen (HLA) haplotypes, that enhance the susceptibility for AIH or influence the severity of the disease. However, as for many other autoimmune diseases, the mere presence of such risk factors does not warrant the occurrence of the disease. Not all individuals carrying risk factors develop AIH, and not all patients with AIH are carriers of high-risk alleles. Thus, additional environmental factors need to be considered as triggers for AIH. Environmental factors include diet, sunlight exposure, stress, medication and hygiene, as well as pathogen infections and vaccinations. This review discusses if pathogens should be considered as triggers for the initiation and/or propagation of AIH.
Identifiants
pubmed: 30113082
doi: 10.1111/cei.13203
pmc: PMC6300650
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-51Informations de copyright
© 2018 British Society for Immunology.
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