Suitability evaluation of new endogenous biomarkers for the identification of nitrite-based urine adulteration in mass spectrometry methods.
Biomarkers
/ urine
Chromatography, Liquid
Cold Temperature
Healthy Volunteers
Histidine
/ urine
Humans
Hydrogen-Ion Concentration
Methylhistidines
/ urine
Nitrites
/ pharmacokinetics
Oxidation-Reduction
Single-Blind Method
Substance Abuse Detection
/ methods
Tandem Mass Spectrometry
/ methods
Uric Acid
/ urine
biomarker identification
high resolution mass spectrometry
metabolomics methods
urine adulteration
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
11
07
2018
revised:
07
08
2018
accepted:
08
08
2018
pubmed:
18
8
2018
medline:
2
7
2019
entrez:
18
8
2018
Statut:
ppublish
Résumé
Urine adulteration to circumvent positive drug testing is a fundamental challenge for toxicological laboratories all over the world. Untargeted mass spectrometry (MS) methods used in metabolomics had previously revealed uric acid (UA), histidine, methylhistidine, and their oxidation products, for example 5-hydroxyisourate (HIU) as potential biomarkers for urine adulteration using potassium nitrite (KNO
Substances chimiques
Biomarkers
0
Methylhistidines
0
Nitrites
0
Uric Acid
268B43MJ25
Histidine
4QD397987E
potassium nitrite
794654G42L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
230-239Informations de copyright
© 2018 John Wiley & Sons, Ltd.