American Football Players in Preseason Training at Risk of Acute Kidney Injury Without Signs of Rhabdomyolysis.
Acclimatization
Acute Kidney Injury
/ etiology
Adult
Asymptomatic Diseases
Athletes
Biomarkers
/ blood
Creatine Kinase
/ blood
Creatinine
/ blood
Football
Glomerular Filtration Rate
Hematuria
/ diagnosis
Hot Temperature
Humans
L-Lactate Dehydrogenase
/ blood
Male
Myoglobin
/ blood
Prospective Studies
Rhabdomyolysis
Students
United States
Journal
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
ISSN: 1536-3724
Titre abrégé: Clin J Sport Med
Pays: United States
ID NLM: 9103300
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
pubmed:
18
8
2018
medline:
24
4
2021
entrez:
18
8
2018
Statut:
ppublish
Résumé
This study was designed to identify changes in blood biomarkers that would indicate excessive muscle breakdown during the initial 10 days of preseason training in collegiate American football players and subsequently increase their risk of acute kidney injury (AKI). Prospective cohort study. Preseason, heat acclimatization period. Twenty-five Division I American football players. Clinical biomarkers for muscle damage were measured during a preseason training camp. Samples were obtained before camp and approximately 5 and 10 days into camp after completion of heat acclimatization training. Creatine kinase, myoglobin, lactate dehydrogenase, and creatinine were measured. Glomerular filtration rate (GFR) was calculated. Urine was collected at each blood draw to qualitatively identify hematuria and red blood cells. A high percentage of athletes had an asymptomatic reduction in kidney function over the 10-day period. Ten of 23 athletes did have a significant, 31.6%, mean reduction in GFR, placing each at risk of AKI according to Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE) classification. The plasma myoglobin for the at risk of AKI group had a mean value 8× above their baseline mean on day 5 and statistically significant mean 13× higher on day 10 than baseline. The not at risk of AKI group did not have significant differences between days 0, 5, and 10. A relatively high percentage of athletes had an asymptomatic reduction in kidney function during the intense preseason training period. 43.4% of athletes in this study had a significant 31.6% mean reduction in GFR over the 10 days. According to RIFLE classification, this placed each athlete "at risk" of AKI.
Identifiants
pubmed: 30119084
doi: 10.1097/JSM.0000000000000652
pii: 00042752-202011000-00007
doi:
Substances chimiques
Biomarkers
0
Myoglobin
0
Creatinine
AYI8EX34EU
L-Lactate Dehydrogenase
EC 1.1.1.27
Creatine Kinase
EC 2.7.3.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
556-561Références
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