Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors.
Adult
Amygdala
/ physiology
Child, Preschool
Female
Functional Neuroimaging
Humans
Hydrocortisone
/ metabolism
Infant, Newborn
Internal-External Control
Magnetic Resonance Imaging
Male
Mothers
/ statistics & numerical data
Neural Pathways
/ physiology
Pregnancy
Saliva
/ metabolism
Sex Characteristics
Time Factors
Young Adult
Amygdala
Cortisol
Infancy
Internalizing
Pregnancy
Resting state functional connectivity MRI
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
01
03
2018
revised:
06
06
2018
accepted:
22
06
2018
pubmed:
21
8
2018
medline:
14
1
2020
entrez:
21
8
2018
Statut:
ppublish
Résumé
Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and psychiatric disorders. Research examining maternal cortisol concentrations across pregnancy and offspring neurodevelopment proximal to birth is needed to advance understanding in this area and lead to insight into the etiology of these disorders. Participants were 70 adult women recruited during early pregnancy and their infants born after 34 weeks gestation. Maternal cortisol concentrations were assessed serially over 4 days in early, mid, and late gestation. Resting state functional connectivity magnetic resonance imaging of the neonatal amygdala was examined. Mothers reported on children's internalizing behavior problems at 24 months of age. Maternal cortisol concentrations during pregnancy were significantly associated with neonatal amygdala connectivity in a sex-specific manner. Elevated maternal cortisol was associated with stronger amygdala connectivity to brain regions involved in sensory processing and integration, as well as the default mode network in girls, and with weaker connectivity to these brain regions in boys. Elevated maternal cortisol was associated with higher internalizing symptoms in girls only, and this association was mediated by stronger neonatal amygdala connectivity. Normative variation in maternal cortisol during pregnancy is associated with the coordinated functioning of the amygdala soon after birth in a sex-specific manner. The identified pathway from maternal cortisol to higher internalizing symptoms in girls via alterations in neonatal amygdala connectivity may be relevant for the etiology of sex differences in internalizing psychiatric disorders, which are more prevalent in women.
Sections du résumé
BACKGROUND
Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and psychiatric disorders. Research examining maternal cortisol concentrations across pregnancy and offspring neurodevelopment proximal to birth is needed to advance understanding in this area and lead to insight into the etiology of these disorders.
METHODS
Participants were 70 adult women recruited during early pregnancy and their infants born after 34 weeks gestation. Maternal cortisol concentrations were assessed serially over 4 days in early, mid, and late gestation. Resting state functional connectivity magnetic resonance imaging of the neonatal amygdala was examined. Mothers reported on children's internalizing behavior problems at 24 months of age.
RESULTS
Maternal cortisol concentrations during pregnancy were significantly associated with neonatal amygdala connectivity in a sex-specific manner. Elevated maternal cortisol was associated with stronger amygdala connectivity to brain regions involved in sensory processing and integration, as well as the default mode network in girls, and with weaker connectivity to these brain regions in boys. Elevated maternal cortisol was associated with higher internalizing symptoms in girls only, and this association was mediated by stronger neonatal amygdala connectivity.
CONCLUSIONS
Normative variation in maternal cortisol during pregnancy is associated with the coordinated functioning of the amygdala soon after birth in a sex-specific manner. The identified pathway from maternal cortisol to higher internalizing symptoms in girls via alterations in neonatal amygdala connectivity may be relevant for the etiology of sex differences in internalizing psychiatric disorders, which are more prevalent in women.
Identifiants
pubmed: 30122286
pii: S0006-3223(18)31665-2
doi: 10.1016/j.biopsych.2018.06.023
pmc: PMC6632079
mid: NIHMS1033768
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-181Subventions
Organisme : NIMH NIH HHS
ID : R01 MH096773
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH091351
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH091238
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD060628
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH111805
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Inc.
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