Premature placental aging in term small-for-gestational-age and growth-restricted fetuses.

To perform a comprehensive assessment of the placental aging process in small term fetuses classified as being small-for-gestational age (SGA) or having fetal growth restriction (FGR) through analysis of senescence and apoptosis markers. This was a prospective nested case-control study of singleton pregnancies delivered at term, including 21 control pregnancies with normally grown fetuses and 36 with a small fetus classified as SGA (birth weight between the 3 Compared to pregnancies with a normally grown fetus, both SGA and FGR pregnancies presented signs of accelerated placental aging, including lower telomerase activity (mean ± SD, 12.8 ± 6.6% in controls vs 7.98 ± 4.2% in SGA vs 7.79 ± 4.6% in FGR; P = 0.008), shorter telomeres (mean ± SD T/S ratio, 1.20 ± 0.6 in controls vs 1.08 ± 0.9 in SGA vs 0.66 ± 0.5 in FGR; P = 0.047) and reduced Sirtuin-1 RNA expression (mean ± SD 2 Accelerated placental aging was observed in both clinical forms of late-onset fetal smallness (SGA and FGR), supporting a common pathophysiology and challenging the concept of SGA fetuses being constitutionally small. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. Envejecimiento prematuro de la placenta en fetos pequeños para la edad gestacional y con restricción del crecimiento OBJETIVO: Realizar una evaluación integral del proceso de envejecimiento de la placenta en fetos a término clasificados como pequeños para la edad gestacional (PEG) o con restricción del crecimiento fetal (RCF) mediante el análisis de los marcadores de senescencia y apoptosis. MÉTODOS: Este fue un estudio prospectivo de casos y controles anidados de embarazos únicos a término, que incluyó 21 embarazos de control con fetos de crecimiento normal y 36 con un feto clasificado como PEG (peso al nacer entre los percentiles 3 足月小于胎龄儿和生长受限胎儿胎盘过早老化 目的: 通过衰老和细胞凋亡标志物分析，对足月小于胎龄儿(SGA)或生长受限(FGR)胎儿的胎盘老化过程进行综合评估。 方法: 这是一项对足月分娩的单胎妊娠进行的前瞻性巢式病例对照研究，研究纳入21例胎儿正常发育的对照组妊娠和36例小胎儿:SGA(出生体重介于3%和9%之间，胎儿胎盘多普勒正常；n=18)或FGR(出生体重<3%和/或脑胎盘比值异常和/或子宫动脉多普勒异常；n=18)。出生时采集胎盘标本，分别检测端粒酶活性、端粒长度(通过将端粒序列(T)的扩增产物数量与基因36B4(S)的单一拷贝扩增产物数量进行比较来量化)及衰老的RNA表达(Sirtuins 1、3、6)和细胞凋亡(p53、p21、BAX、Caspases 3、9)标志物(利用2

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Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.