Identification of the benztropine analog [
Benztropine
Cocaine
Molecular modeling
Peptide mapping
Photoaffinity labeling
SCAM
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
01
06
2018
revised:
10
08
2018
accepted:
14
08
2018
pubmed:
21
8
2018
medline:
27
12
2019
entrez:
21
8
2018
Statut:
ppublish
Résumé
The dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA neurotransmission. Cocaine and many psychostimulant drugs bind to DAT and block reuptake, inducing DA overflow that forms the neurochemical basis for euphoria and addiction. Paradoxically, however, some ligands such as benztropine (BZT) bind to DAT and inhibit reuptake but do not produce these effects, and it has been hypothesized that differential mechanisms of binding may stabilize specific transporter conformations that affect downstream neurochemical or behavioral outcomes. To investigate the binding mechanisms of BZT on DAT we used the photoaffinity BZT analog [
Identifiants
pubmed: 30125594
pii: S0197-0186(18)30241-9
doi: 10.1016/j.neuint.2018.08.008
pmc: PMC8295913
mid: NIHMS1717683
pii:
doi:
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Dopamine Uptake Inhibitors
0
Iodine Radioisotopes
0
Benztropine
1NHL2J4X8K
Iodine-125
GVO776611R
Cocaine
I5Y540LHVR
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-45Subventions
Organisme : NIDA NIH HHS
ID : R01 DA027845
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DA000389
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000389
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000610
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.
Références
Nature. 2013 Nov 7;503(7474):85-90
pubmed: 24037379
PLoS One. 2011 Jan 27;6(1):e16350
pubmed: 21298009
J Pharmacol Exp Ther. 2005 Aug;314(2):906-15
pubmed: 15860577
Life Sci. 1990;46(20):PL17-21
pubmed: 2111866
Mol Cell. 2008 Jun 20;30(6):667-77
pubmed: 18570870
J Biol Chem. 1997 Jun 13;272(24):15541-6
pubmed: 9182590
J Pharmacol Exp Ther. 2004 May;309(2):650-60
pubmed: 14755006
Nature. 2007 Aug 23;448(7156):952-6
pubmed: 17687333
J Chem Theory Comput. 2008 Mar;4(3):435-47
pubmed: 26620784
J Biol Chem. 2012 Nov 16;287(47):39316-26
pubmed: 23007398
J Biol Chem. 2014 Jan 17;289(3):1825-40
pubmed: 24293367
J Biol Chem. 2007 Mar 23;282(12):8915-25
pubmed: 17255098
Neuropharmacology. 2005 Nov;49(6):759-68
pubmed: 16181646
J Biol Chem. 2012 May 25;287(22):18524-34
pubmed: 22451652
PLoS Comput Biol. 2011 Oct;7(10):e1002246
pubmed: 22046120
Trends Pharmacol Sci. 2013 Sep;34(9):489-96
pubmed: 23968642
Science. 2008 Dec 12;322(5908):1655-61
pubmed: 19074341
Nature. 2005 Sep 8;437(7056):215-23
pubmed: 16041361
J Biol Chem. 2005 Dec 9;280(49):40442-9
pubmed: 16204245
J Neurochem. 2005 Jan;92(1):21-8
pubmed: 15606893
J Neurosci. 1999 Jan 15;19(2):630-6
pubmed: 9880583
Pflugers Arch. 2014 Jan;466(1):25-42
pubmed: 24337881
Psychopharmacology (Berl). 2001 Apr;154(4):362-74
pubmed: 11349389
J Biol Chem. 2002 Jul 12;277(28):25178-86
pubmed: 11994276
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8
pubmed: 19307590
J Pharmacol Exp Ther. 1999 Jan;288(1):302-15
pubmed: 9862785
Nat Commun. 2017 Dec 20;8(1):2228
pubmed: 29263318
Pharmacol Biochem Behav. 1997 Jul;57(3):505-12
pubmed: 9218275
Nature. 2015 May 21;521(7552):322-7
pubmed: 25970245
Nat Neurosci. 2008 Jul;11(7):780-9
pubmed: 18568020
Top Curr Chem. 2012;324:85-113
pubmed: 22028098
Nat Struct Mol Biol. 2009 Jun;16(6):652-7
pubmed: 19430461
J Biol Chem. 2014 Oct 24;289(43):29712-27
pubmed: 25179220
Nat Struct Mol Biol. 2015 Jun;22(6):506-508
pubmed: 25961798
Front Neurol. 2015 Jun 09;6:134
pubmed: 26106364
J Med Chem. 2017 Dec 28;60(24):10172-10187
pubmed: 29227643
Eur J Pharmacol. 2003 Oct 31;479(1-3):23-40
pubmed: 14612135
Pharmacogenomics J. 2002;2(4):217-35
pubmed: 12196911
Nature. 2011 Jun 2;474(7349):109-13
pubmed: 21516104
Handb Exp Pharmacol. 2017;244:177-218
pubmed: 28110353
Drug Alcohol Depend. 2015 Feb 1;147:1-19
pubmed: 25548026
J Neurosci. 2005 Feb 23;25(8):1889-93
pubmed: 15728828
Biochem Pharmacol. 2017 Oct 15;142:204-215
pubmed: 28734777
Br J Pharmacol. 2012 Sep;167(2):256-78
pubmed: 22519513
Synapse. 2016 Mar;70(3):98-111
pubmed: 26618331
Trends Pharmacol Sci. 2006 Jul;27(7):375-83
pubmed: 16762425
PLoS One. 2011;6(10):e25790
pubmed: 22043293
Mol Pharmacol. 2008 Apr;73(4):1141-50
pubmed: 18216182
Science. 2007 Sep 7;317(5843):1390-3
pubmed: 17690258
Mol Pharmacol. 1995 May;47(5):956-64
pubmed: 7746282
Neurosci Lett. 2018 Apr 3;671:88-92
pubmed: 29452175
J Neurochem. 2008 Nov;107(4):928-40
pubmed: 18786172
J Biol Chem. 2001 Aug 3;276(31):29012-8
pubmed: 11395483
ACS Chem Neurosci. 2017 Aug 16;8(8):1735-1746
pubmed: 28441487
Annu Rev Neurosci. 1993;16:73-93
pubmed: 8096377
Structure. 2015 Nov 3;23(11):2171-81
pubmed: 26481814
J Chem Neuroanat. 2017 Oct;83-84:3-9
pubmed: 28115272
J Biol Chem. 2003 Sep 26;278(39):37052-63
pubmed: 12869570
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10338-43
pubmed: 18647834
Mol Psychiatry. 2000 May;5(3):275-82
pubmed: 10889530
Nature. 2016 Apr 21;532(7599):334-9
pubmed: 27049939
J Biol Chem. 2013 Jan 4;288(1):20-32
pubmed: 23161550
Mol Aspects Med. 2013 Apr-Jun;34(2-3):197-219
pubmed: 23506866
J Biol Chem. 2011 Sep 2;286(35):30823-30836
pubmed: 21730057
J Pharmacol Exp Ther. 2017 Jul;362(1):2-13
pubmed: 28442581
Biochem Pharmacol. 2016 Nov 15;120:46-55
pubmed: 27638414
Neuropharmacology. 2011 Jan;60(1):182-90
pubmed: 20816875
Mol Pharmacol. 2004 Mar;65(3):692-701
pubmed: 14978248
J Biol Chem. 2017 Nov 17;292(46):19066-19075
pubmed: 28939767
J Mol Biol. 2009 Jan 16;385(2):381-92
pubmed: 19041878
Med Res Rev. 2002 Sep;22(5):429-64
pubmed: 12210554
Trends Neurosci. 1991 Jul;14(7):299-302
pubmed: 1719677
Br J Pharmacol. 2016 Mar;173(5):925-36
pubmed: 26699847
J Med Chem. 1997 Dec 19;40(26):4329-39
pubmed: 9435902
Nature. 1966 Aug 27;211(5052):969-70
pubmed: 5968307
J Biol Chem. 2004 Jan 30;279(5):3228-38
pubmed: 14597628
Lancet Neurol. 2011 Jan;10(1):54-62
pubmed: 21112253
J Med Chem. 1995 Sep 29;38(20):3933-40
pubmed: 7562926
Prog Neurobiol. 2005 Apr;75(6):406-33
pubmed: 15955613
J Biol Chem. 1996 Aug 30;271(35):21672-80
pubmed: 8702957
Neuropharmacology. 2018 Mar 15;131:96-103
pubmed: 29217282
J Pharmacol Exp Ther. 2009 May;329(2):677-86
pubmed: 19228996
J Chem Neuroanat. 2017 Oct;83-84:10-18
pubmed: 27836487
Nature. 2012 Jan 09;481(7382):469-74
pubmed: 22230955
Biochem Pharmacol. 2008 Jan 1;75(1):2-16
pubmed: 17897630
J Biol Chem. 2012 Aug 24;287(35):29702-12
pubmed: 22722938
J Neurochem. 2004 May;89(4):853-64
pubmed: 15140185
Neuropsychopharmacology. 2017 Aug;42(9):1871-1883
pubmed: 28266501
Synapse. 2004 Sep 1;53(3):176-83
pubmed: 15236350
J Med Chem. 2016 Dec 8;59(23):10676-10691
pubmed: 27933960
Nat Protoc. 2013;8(7):1277-98
pubmed: 23744289
J Med Chem. 1994 Jul 22;37(15):2258-61
pubmed: 8057273
J Pharmacol Exp Ther. 2015 Jun;353(3):529-38
pubmed: 25788711
Pharmacol Rev. 2011 Sep;63(3):585-640
pubmed: 21752877
J Pharmacol Exp Ther. 2005 Aug;314(2):575-83
pubmed: 15879005
J Clin Invest. 2009 Jun;119(6):1595-603
pubmed: 19478460
J Biol Chem. 2016 Jan 15;291(3):1456-71
pubmed: 26582198
J Biol Chem. 2017 Jul 7;292(27):11250-11261
pubmed: 28495886
Biol Psychiatry. 2014 Nov 15;76(10):802-9
pubmed: 24853388