New insights into immune mechanisms of antiperlecan/LG3 antibody production: Importance of T cells and innate B1 cells.
B cell biology
animal models
autoantibody
basic (laboratory) research/science
cell death: apoptosis
cellular biology
clinical research/practice
immunobiology
kidney transplantation/nephrology
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
07
05
2018
revised:
25
07
2018
accepted:
29
07
2018
pubmed:
22
8
2018
medline:
14
7
2020
entrez:
22
8
2018
Statut:
ppublish
Résumé
Autoantibodies against perlecan/LG3 (anti-LG3) have been associated with increased risks of delayed graft function, acute rejection, and reduced long-term survival. High titers of anti-LG3 antibodies have been found in de novo renal transplants recipients in the absence of allosensitizing or autoimmune conditions. Here, we seek to understand the pathways controlling anti-LG3 production prior to transplantation. Mice immunized with recombinant LG3 produce concomitantly IgM and IgG anti-LG3 antibodies suggesting a memory response. ELISpot confirmed the presence of LG3-specific memory B cells in nonimmunized mice. Purification of B1 and B2 subtypes identified peritoneal B1 cells as the major source of memory B cells reactive to LG3. Although nonimmunized CD4-deficient mice were found to express LG3-specific memory B cells, depletion of CD4
Identifiants
pubmed: 30129231
doi: 10.1111/ajt.15082
pmc: PMC6519043
pii: S1600-6135(22)08984-5
doi:
Substances chimiques
Autoantibodies
0
Heparan Sulfate Proteoglycans
0
perlecan
143972-95-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-712Subventions
Organisme : CIHR
ID : MOP-123436
Pays : Canada
Organisme : CIHR
ID : PJT-148884
Pays : Canada
Organisme : Kidney Foundation of Canada
ID : KFOC 150009
Pays : International
Informations de copyright
© 2018 The Authors American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
Références
Am J Transplant. 2012 Aug;12(8):2088-97
pubmed: 22510337
J Am Soc Nephrol. 2017 Feb;28(2):400-406
pubmed: 27798244
Blood Purif. 2015;39(1-3):84-92
pubmed: 25662331
Transplantation. 2010 May 27;89(10):1239-46
pubmed: 20445487
Clin Exp Immunol. 2001 Oct;126(1):173-9
pubmed: 11678915
Ann Thorac Surg. 2010 Oct;90(4):1094-101
pubmed: 20868794
J Biol Chem. 2008 Oct 3;283(40):27220-9
pubmed: 18658137
Am J Transplant. 2014 Mar;14(3):685-93
pubmed: 24410875
Sci Transl Med. 2015 Dec 16;7(318):318ra200
pubmed: 26676607
Immunity. 2004 Sep;21(3):379-90
pubmed: 15357949
J Exp Med. 2006 Feb 20;203(2):305-10
pubmed: 16476769
J Biol Chem. 2006 Oct 13;281(41):30383-92
pubmed: 16882656
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5388-93
pubmed: 22421135
Am J Transplant. 2016 Dec;16(12):3416-3429
pubmed: 27172087
Nat Rev Immunol. 2011 Jan;11(1):34-46
pubmed: 21151033
J Immunol. 2009 May 1;182(9):5363-73
pubmed: 19380783
Semin Dial. 2002 Sep-Oct;15(5):329-37
pubmed: 12358637
CSH Protoc. 2008 Mar 01;2008:pdb.prot4980
pubmed: 21356796
Clin Exp Immunol. 2015 Jun;180(3):542-50
pubmed: 25682989
Am J Transplant. 2013 Apr;13(4):861-874
pubmed: 23432943
Ann Rheum Dis. 2010 Jan;69 Suppl 1:i92-96
pubmed: 19995755
Transplantation. 2016 Oct;100(10):2194-202
pubmed: 26636737
Nucleic Acids Res. 2002 Jan 15;30(2):E9
pubmed: 11788735
Kidney Int. 2011 Mar;79(6):655-662
pubmed: 20980975
J Vis Exp. 2010 Jan 28;(35):
pubmed: 20110936
J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S274-80
pubmed: 17130274
Am J Transplant. 2017 Feb;17(2):462-473
pubmed: 27343461
Front Immunol. 2016 Aug 12;7:307
pubmed: 27570526
Mol Immunol. 2008 Sep;45(15):4036-9
pubmed: 18672288
Transpl Int. 2015 Dec;28(12):1371-82
pubmed: 26303035
J Heart Lung Transplant. 2004 Feb;23(2):204-9
pubmed: 14761768
Am J Transplant. 2014 Oct;14(10):2359-66
pubmed: 25220332
J Heart Lung Transplant. 2016 Jan;35(1):87-91
pubmed: 26422083
Am J Transplant. 2005 Feb;5(2):383-93
pubmed: 15643999
Am J Transplant. 2013 Oct;13(10):2590-600
pubmed: 23919437
Am J Transplant. 2013 Oct;13(10):2567-76
pubmed: 23919486
Comp Immunol Microbiol Infect Dis. 2017 Oct;54:38-44
pubmed: 28916000
Am J Pathol. 2007 Apr;170(4):1415-27
pubmed: 17392180
J Immunol. 2003 Jun 15;170(12):6151-7
pubmed: 12794145
J Immunol. 2006 Sep 1;177(5):2749-54
pubmed: 16920907
Curr Opin Immunol. 2011 Jun;23(3):330-6
pubmed: 21482090
N Engl J Med. 2005 Feb 10;352(6):558-69
pubmed: 15703421
J Heart Lung Transplant. 2016 Sep;35(9):1067-77
pubmed: 27373824
Biochemistry. 2005 Dec 6;44(48):15705-14
pubmed: 16313173
Curr Opin Immunol. 2006 Oct;18(5):547-55
pubmed: 16879952
Expert Opin Biol Ther. 2007 Oct;7(10):1575-82
pubmed: 17916049
Trends Immunol. 2006 Sep;27(9):428-33
pubmed: 16861037
Am J Transplant. 2019 Mar;19(3):699-712
pubmed: 30129231
J Immunol. 2011 Jul 15;187(2):1023-30
pubmed: 21677143
Am J Transplant. 2014 Jul;14(7):1581-91
pubmed: 24935695
Transplantation. 2001 Apr 15;71(7):886-92
pubmed: 11349721
Ann N Y Acad Sci. 1993 Nov 30;696:9-19
pubmed: 7509138
Nephrol Dial Transplant. 2017 Jul 1;32(7):1244-1250
pubmed: 26546592
Blood. 2006 Aug 1;108(3):974-82
pubmed: 16861350
J Am Soc Nephrol. 2018 Jun;29(6):1761-1770
pubmed: 29602833