Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
Aged
Aged, 80 and over
Arginine
/ analogs & derivatives
Case-Control Studies
Citrulline
/ blood
Cohort Studies
Diabetes Mellitus, Type 2
/ blood
Diet, Fat-Restricted
/ statistics & numerical data
Diet, Mediterranean
/ statistics & numerical data
Female
Humans
Incidence
Insulin Resistance
/ physiology
Male
Middle Aged
Ornithine
/ blood
Risk Factors
omega-N-Methylarginine
/ blood
cohort study
dietary intervention
insulin resistance
observational study
population study, type 2 diabetes
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
15
05
2018
revised:
16
08
2018
accepted:
23
08
2018
pubmed:
28
8
2018
medline:
10
9
2019
entrez:
28
8
2018
Statut:
ppublish
Résumé
The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
Identifiants
pubmed: 30146690
doi: 10.1111/dom.13514
pmc: PMC6329637
mid: NIHMS986825
doi:
Substances chimiques
omega-N-Methylarginine
27JT06E6GR
Citrulline
29VT07BGDA
symmetric dimethylarginine
49787G1ULV
N,N-dimethylarginine
63CV1GEK3Y
Arginine
94ZLA3W45F
Ornithine
E524N2IXA3
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
397-401Subventions
Organisme : NIDDK NIH HHS
ID : F31 DK114938
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK119412
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102896
Pays : United States
Informations de copyright
© 2018 John Wiley & Sons Ltd.
Références
PLoS One. 2016 Nov 3;11(11):e0165811
pubmed: 27812151
Diabetes Obes Metab. 2012 Oct;14(10):893-900
pubmed: 22553931
J Clin Epidemiol. 1999 Dec;52(12):1165-72
pubmed: 10580779
Ann Intern Med. 2014 Jan 7;160(1):1-10
pubmed: 24573661
Diabetes Obes Metab. 2000 Oct;2(5):285-92
pubmed: 11225743
Nephrol Dial Transplant. 2006 Sep;21(9):2446-51
pubmed: 16766542
Diabetologia. 2010 Oct;53(10):2093-104
pubmed: 20496053
Diabetes Obes Metab. 2007 Jul;9(4):455-63
pubmed: 17587387
Diabetes Care. 2003 Jan;26(1):168-71
pubmed: 12502675
J Am Coll Cardiol. 2009 Jun 2;53(22):2061-7
pubmed: 19477356
PLoS One. 2013 Jun 24;8(6):e66823
pubmed: 23826148
J Clin Invest. 2017 Dec 1;127(12):4394-4402
pubmed: 29083323
Diabetes Care. 2001 May;24(5):875-80
pubmed: 11347747
N Engl J Med. 1993 Dec 30;329(27):2002-12
pubmed: 7504210
Diabetes Obes Metab. 2018 Jun;20(6):1350-1360
pubmed: 29419909
Sci Rep. 2015 Jul 09;5:11918
pubmed: 26156880
J Am Diet Assoc. 2008 Jul;108(7):1134-44; discussion 1145
pubmed: 18589019
Curr Protein Pept Sci. 2017;18(6):599-608
pubmed: 27356939
Rev Diabet Stud. 2010 Spring;7(1):15-25
pubmed: 20703435
Diabetes Obes Metab. 2010 Oct;12 Suppl 2:126-33
pubmed: 21029309