A unified circuit for social behavior.

Amygdala / physiology Animals Brain / physiology Hippocampus / physiology Humans Hypothalamus / physiology Neural Pathways / physiology Optogenetics Prefrontal Cortex / physiology Social Behavior Social Environment Ventral Striatum / physiology
Autism Chemogenetics Circuit Optogenetics Shank3 Social behavior Tuberous sclerosis

Journal

Neurobiology of learning and memory
ISSN: 1095-9564
Titre abrégé: Neurobiol Learn Mem
Pays: United States
ID NLM: 9508166

Informations de publication

Date de publication:
11 2019
Historique:
received: 02 03 2018
revised: 04 08 2018
accepted: 14 08 2018
pubmed: 28 8 2018
medline: 31 7 2020
entrez: 28 8 2018
Statut: ppublish

Résumé

Recent advances in circuit manipulation technologies have enabled the association of distinct neural circuits with complex social behaviors. The brain areas identified through historical anatomical characterizations as mediators of sexual and parental behaviors can now be functionally linked to adult social behaviors within a unified circuit. In vivo electrophysiology, optogenetics and chemogenetics have been used to follow the processing of social sensory stimuli from perception by the olfactory system to valence detection by the amygdala and mesolimbic dopamine system to integration by the cerebral and cerebellar cortices under modulation of hypothalamic neuropeptides. Further, these techniques have been able to identify the distinct functional changes induced by social as opposed to non-social stimuli. Together this evidence suggests that there is a distinct, functionally coupled circuit that is selectively activated by social stimuli. A unified social circuit provides a new framework against which synaptopathic autism related mutations can be considered and novel pharmacotherapeutic strategies can be developed.

Identifiants

DOI: 10.1016/j.nlm.2018.08.010 PMID: 30149055 PMC: PMC6387844
pubmed: 30149055
pii: S1074-7427(18)30195-3
doi: 10.1016/j.nlm.2018.08.010
pmc: PMC6387844
mid: NIHMS1508469
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

106920

Subventions

Organisme : NINDS NIH HHS
ID : U01 NS092595
Pays : United States
Organisme : NCATS NIH HHS
ID : U2C TR002818
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS092090
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS082320
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Meera E Modi (ME)

Translational Neuroscience Center, F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, United States.

Mustafa Sahin (M)

Translational Neuroscience Center, F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, United States. Electronic address: mustafa.sahin@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › A unified circuit for social behavior.
questionsmedicales.fr › Eucaryotes › Animaux › A unified circuit for social behavior.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › A unified circuit for social behavior.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › A unified circuit for social behavior.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A unified circuit for social behavior.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › A unified circuit for social behavior.
questionsmedicales.fr › Système nerveux › Voies nerveuses › A unified circuit for social behavior.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Optogénétique › A unified circuit for social behavior.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › A unified circuit for social behavior.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › A unified circuit for social behavior.
questionsmedicales.fr › Sciences sociales › Sociologie › Facteurs sociologiques › Environnement social › A unified circuit for social behavior.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › A unified circuit for social behavior.