Screening and determination for potential acetylcholinesterase inhibitory constituents from ginseng stem-leaf saponins using ultrafiltration (UF)-LC-ESI-MS
Acetylcholinesterase
/ drug effects
Cholinesterase Inhibitors
/ analysis
Chromatography, Liquid
/ methods
Feasibility Studies
Panax
/ chemistry
Plant Leaves
/ chemistry
Plant Stems
/ chemistry
Protein Binding
Saponins
/ analysis
Spectrometry, Mass, Electrospray Ionization
/ methods
Tandem Mass Spectrometry
/ methods
Ultrafiltration
/ methods
AChE inhibitor
UF-LC-ESI-MS2
ginseng stem-leaf saponin
ginsenoside
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
04
03
2018
revised:
01
07
2018
accepted:
08
07
2018
pubmed:
31
8
2018
medline:
1
2
2019
entrez:
31
8
2018
Statut:
ppublish
Résumé
Previous studies have demonstrated that several ginsenosides have remarkable inhibitory effect on acetylcholinesterase (AChE). In the present study, ginseng stem-leaf saponins (GSLS) can improve learning and memory of Alzheimer's disease patients. However, much comprehensive information regarding AChE inhibition of GSLS and its metabolites is yet unknown. The present study aims to screen and determine the potential of AChE inhibitors (AChEIs) from GSLS. The active fraction of the GSLS detected in vitro AChE inhibition assays was selected as a starting material for the screening of the potential of AChEIs using ultrafiltration liquid chromatography coupled to electrospray ionisation tandem mass spectrometry (UF-LC-ESI-MS The results showed that 31 ginsenosides were identified with analysis using rapid resolution liquid chromatography with a diode array detector combined with electrospray ionisation tandem mass spectrometry (RRLC-DAD-ESI-MS The proposed UF-LC-ESI-MS
Substances chimiques
Cholinesterase Inhibitors
0
Saponins
0
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-33Subventions
Organisme : National Natural Science Foundation of China
ID : 81704001
Organisme : National Natural Science Foundation of China
ID : 31570347
Organisme : National Health and Family Planning Commission of Jilin Province
ID : 2015Z067
Informations de copyright
© 2018 John Wiley & Sons, Ltd.