Apoptotic PET Imaging of Rat Pulmonary Fibrosis with Small-Molecule Radiotracer.

Animals Apoptosis Bleomycin Collagen / metabolism Fluorodeoxyglucose F18 / chemistry Lung / diagnostic imaging Male Methylmalonic Acid / analogs & derivatives Positron Emission Tomography Computed Tomography Positron-Emission Tomography Pulmonary Fibrosis / diagnostic imaging Radiopharmaceuticals / chemistry Rats, Sprague-Dawley
Bleomycin PET/CT Pulmonary fibrosis [18F]FDG [18F]ML-10

Journal

Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610

Informations de publication

Date de publication:
06 2019
Historique:
pubmed: 1 9 2018
medline: 6 5 2020
entrez: 1 9 2018
Statut: ppublish

Résumé

The purpose of this study was to assess the potential utility of small-molecule apoptotic radiotracer, 2-(5-[ Male Sprague-Dawley rats were used to establish a rat model of pulmonary fibrosis by means of bleomycin (BLM) administration; control rats received saline (n = 12 per group). PET/CT with [ Compared with control group, BLM group showed a higher lung uptake of [ [

Identifiants

DOI: 10.1007/s11307-018-1242-7 PMID: 30167994
pubmed: 30167994
doi: 10.1007/s11307-018-1242-7
pii: 10.1007/s11307-018-1242-7
doi:

Substances chimiques

5-fluoropentyl-2-methylmalonic acid 0
Radiopharmaceuticals 0
Fluorodeoxyglucose F18 0Z5B2CJX4D
Bleomycin 11056-06-7
Methylmalonic Acid 8LL8S712J7
Collagen 9007-34-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

491-499

Références

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Auteurs

Ying Xiong (Y)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Dahong Nie (D)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Shaoyu Liu (S)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Hui Ma (H)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Shu Su (S)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Aixia Sun (A)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Jing Zhao (J)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Zhanwen Zhang (Z)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China.

Xianhong Xiang (X)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China. xxianhong@mail.sysu.edu.cn.

Ganghua Tang (G)

Department of Medical Imaging and Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, China. tangghua@mail.sysu.edu.cn.
ORCID: 0000-0001-6288-5578

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Glycopeptides › Bléomycine › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Fluorodésoxyglucose F18 › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Appareil respiratoire › Poumon › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Malonates › Acide méthyl-malonique › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Fibrose pulmonaire › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Apoptotic PET Imaging of Rat Pulmonary...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Apoptotic PET Imaging of Rat Pulmonary...