Deficits in response inhibition on varied levels of demand load in anorexia nervosa: an event-related potentials study.
Anorexia nervosa
Event-related potentials
N2
P300
Response inhibition.
Stop-signal task
Journal
Eating and weight disorders : EWD
ISSN: 1590-1262
Titre abrégé: Eat Weight Disord
Pays: Germany
ID NLM: 9707113
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
08
12
2017
accepted:
30
07
2018
pubmed:
1
9
2018
medline:
15
12
2020
entrez:
1
9
2018
Statut:
ppublish
Résumé
The aim of the present study was to investigate the executive function of inhibitory control in anorexia nervosa (AN), which is considered as an underlying pathophysiology of restricting eating. In this work, we examined the function of response inhibition in 27 unmedicated AN patients and 30 healthy controls (HC) using stop-signal tasks with different demand loads. Two event-related potentials (ERP) during the stop-signal tasks, N2 and P300, were compared between the AN and HC groups. We found attenuated P300 amplitudes and delayed N2 latencies in AN patients across all three demand loads compared to HCs. We also found significant interaction between group and level of demand load. N2 latencies were prolonged when the inhibitory demand was lower in the AN group, whereas no differences in N2 latencies were found across different demand loads in HCs. Taken together, altered P300 amplitudes and N2 latencies may be associated with impaired response inhibition in AN patients. In particular, alterations of fronto-central N2 activations were demand-related, which might contribute to an aberrant inhibitory control process in AN. Level II, controlled trial without randomization.
Identifiants
pubmed: 30168032
doi: 10.1007/s40519-018-0558-2
pii: 10.1007/s40519-018-0558-2
pmc: PMC6997249
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
231-240Subventions
Organisme : the National Natural Science Foundation
ID : 81771461
Organisme : Natural Science Foundation of Shanghai
ID : 16ZR1430400
Organisme : Natural Science Foundation of Shanghai
ID : 17ZR1424700
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 16411965200
Organisme : Shanghai Municipal Population and Family Planning Commission
ID : 201640050
Organisme : Shanghai Municipal Population and Family Planning Commission
ID : 20144Y0081
Organisme : Shanghai Jiao Tong University
ID : YG2016MS36
Organisme : Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai
ID : 2017YQ069
Organisme : the National Key Clinical Disciplines at Shanghai Mental Health Centre
ID : Office of Medical Affairs, Ministry of Health, 2011-873; OMA-MH, 2011-873
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