Aspergillus terreus Causing Probable Invasive Aspergillosis in a Patient with Cystic Fibrosis.
Aspergillus terreus
Cystic fibrosis
Emerging
Invasive aspergillosis
Journal
Mycopathologia
ISSN: 1573-0832
Titre abrégé: Mycopathologia
Pays: Netherlands
ID NLM: 7505689
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
24
01
2018
accepted:
13
08
2018
pubmed:
1
9
2018
medline:
19
3
2019
entrez:
1
9
2018
Statut:
ppublish
Résumé
Aspergillus terreus may colonize the airways of patients with cystic fibrosis (CF). Whether this merits antifungal treatment is still unclear due to heterogeneous reports regarding its pathogenic potential. Although allergic manifestations are documented, invasive aspergillosis (IA) caused by A. terreus has not been described. We present here one case of probable IA caused by A. terreus, highlighting its role as an emerging agent of IA in CF patients. Voriconazole was effective, and the patient was healthy after 12 weeks of treatment. Serial determination of serum galactomannan level and periodic cultures from respiratory specimens may help in monitoring CF patients by identifying such pathogens. Further studies on the fungal species colonizing the CF airways are warranted, especially in India. This case report suggests A. terreus as a potential agent of IA which should not be ignored, particularly in this patient group.
Identifiants
pubmed: 30168076
doi: 10.1007/s11046-018-0294-1
pii: 10.1007/s11046-018-0294-1
doi:
Substances chimiques
Antifungal Agents
0
Mannans
0
galactomannan
11078-30-1
Voriconazole
JFU09I87TR
Galactose
X2RN3Q8DNE
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-154Références
Clin Infect Dis. 2002 Nov 1;35(9):e106-10
pubmed: 12384856
Clin Infect Dis. 2003 Oct 1;37 Suppl 3:S225-64
pubmed: 12975753
J Pediatr. 2008 Aug;153(2):S4-S14
pubmed: 18639722
Med Mycol. 2011 Apr;49 Suppl 1:S35-47
pubmed: 20718613
Pediatr Infect Dis J. 2011 Feb;30(2):178-80
pubmed: 20823780
Nat Med. 2012 Apr 05;18(4):509-19
pubmed: 22481418
Med Mycol. 2012 Aug;50(6):658-60
pubmed: 22524639
J Assoc Physicians India. 2012 Aug;60:39-41
pubmed: 23405520
Clin Microbiol Infect. 2014 Apr;20(4):327-33
pubmed: 23927682
Curr Opin Pulm Med. 2013 Nov;19(6):670-5
pubmed: 24060984
BMJ Case Rep. 2013 Nov 18;2013:null
pubmed: 24248318
J Antimicrob Chemother. 2014 Nov;69(11):3148-55
pubmed: 25006241
Med Mycol. 2014 Oct;52(7):715-22
pubmed: 25056962
Clin Exp Allergy. 2015 Dec;45(12):1765-78
pubmed: 26177981
Med Mycol Case Rep. 2015 Jul 29;9:26-30
pubmed: 26288746
Respir Investig. 2016 Mar;54(2):76-84
pubmed: 26879476
Infect Drug Resist. 2016 Sep 20;9:229-238
pubmed: 27703383