Genetics of alcohol use disorder: a review.
Journal
Current opinion in psychology
ISSN: 2352-2518
Titre abrégé: Curr Opin Psychol
Pays: Netherlands
ID NLM: 101649136
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
23
06
2018
revised:
25
07
2018
accepted:
31
07
2018
pubmed:
1
9
2018
medline:
16
7
2020
entrez:
1
9
2018
Statut:
ppublish
Résumé
Alcohol use disorder (AUD) represents a significant and ongoing public health concern with 12-month prevalence estimates of ∼5.6%. Quantitative genetic studies suggest a heritability of approximately 50% for AUD, and as a result, significant efforts have been made to identify specific variation within the genome related to the etiology of AUD. Given the limited number of replicable findings that have emerged from genome-wide linkage and candidate gene association studies, more recent efforts have focused on the use of genome-wide association studies (GWAS). These studies have suggested that hundreds of variants across the genome, most of small effect (R
Identifiants
pubmed: 30170251
pii: S2352-250X(18)30111-8
doi: 10.1016/j.copsyc.2018.07.012
pmc: PMC6368900
mid: NIHMS1503304
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-61Subventions
Organisme : NIAAA NIH HHS
ID : F31 AA025516
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA013526
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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