Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer.

17-Hydroxysteroid Dehydrogenases / genetics Adrenal Glands / pathology Adrenalectomy Aldo-Keto Reductase Family 1 Member C3 / genetics Androgens / biosynthesis Animals Cell Line, Tumor Cell Proliferation / genetics Gene Expression Regulation, Neoplastic Heterografts Humans Male Mice Multienzyme Complexes / genetics Neoplasm Recurrence, Local Progesterone Reductase / genetics Prostatic Neoplasms, Castration-Resistant / genetics Receptors, Androgen / genetics Steroid 17-alpha-Hydroxylase / genetics Steroid Isomerases / genetics Testosterone / genetics

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
01 01 2019
Historique:
received: 09 05 2018
revised: 01 08 2018
accepted: 29 08 2018
pubmed: 6 9 2018
medline: 27 2 2020
entrez: 6 9 2018
Statut: ppublish

Résumé

Tumor androgens in castration-resistant prostate cancer (CRPC) reflect We evaluated tumor growth and androgens in LuCaP35CR and LuCaP96CR xenografts in response to adrenalectomy (ADX). We assessed protein expression of key steroidogenic enzymes in 185 CRPC metastases from 42 patients. Adrenal glands of intact and castrated mice expressed CYP17A. Serum DHEA, androstenedione (AED), and testosterone (T) in castrated mice became undetectable after ADX (all Mice are appropriate for evaluating adrenal impact of steroidogenesis inhibitors. A subset of ADX-resistant CRPC tumors demonstrate

Identifiants

DOI: 10.1158/1078-0432.CCR-18-1431 PMID: 30181386 PMC: PMC6320302
pubmed: 30181386
pii: 1078-0432.CCR-18-1431
doi: 10.1158/1078-0432.CCR-18-1431
pmc: PMC6320302
mid: NIHMS1505837
doi:

Substances chimiques

3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase 0
AR protein, human 0
Androgens 0
Multienzyme Complexes 0
Receptors, Androgen 0
Testosterone 3XMK78S47O
17-Hydroxysteroid Dehydrogenases EC 1.1.-
17beta-hydroxysteroid dehydrogenase type 3 EC 1.1.-
Progesterone Reductase EC 1.1.1.145
AKR1C3 protein, human EC 1.1.1.357
Aldo-Keto Reductase Family 1 Member C3 EC 1.1.1.357
CYP17A1 protein, human EC 1.14.14.19
Steroid 17-alpha-Hydroxylase EC 1.14.14.19
Steroid Isomerases EC 5.3.3.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

426-439

Subventions

Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097186
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002319
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000423
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA163227
Pays : United States

Informations de copyright

©2018 American Association for Cancer Research.

Références

Endocrinology. 1997 Aug;138(8):3166-74
pubmed: 9231764
J Steroid Biochem Mol Biol. 1992 Dec;43(8):951-60
pubmed: 22217840
Prostate. 2013 Sep;73(12):1316-25
pubmed: 23775398
Exp Clin Endocrinol. 1989 Apr;93(1):83-9
pubmed: 2737242
J Clin Oncol. 2014 Nov 20;32(33):3705-15
pubmed: 25311217
BJU Int. 2009 Aug;104(3):406-11
pubmed: 19239443
N Engl J Med. 2017 Jul 27;377(4):352-360
pubmed: 28578607
PLoS One. 2011;6(11):e27970
pubmed: 22114732
Clin Cancer Res. 2011 Sep 15;17(18):5913-25
pubmed: 21807635
Talanta. 2009 Dec 15;80(2):826-32
pubmed: 19836559
Cancer Res. 2010 Feb 1;70(3):1256-64
pubmed: 20086173
Cancer Res. 2006 Mar 1;66(5):2815-25
pubmed: 16510604
Nature. 2015 Jul 16;523(7560):347-51
pubmed: 26030522
Mol Cell Endocrinol. 2016 Feb 5;421:82-97
pubmed: 26678830
Cancer Res. 2009 Jan 1;69(1):16-22
pubmed: 19117982
Prostate. 2016 Jun;76(9):810-22
pubmed: 26990456
Horm Metab Res. 1988 Feb;20(2):96-9
pubmed: 2967241
J Endocrinol. 1979 Dec;83(3):435-47
pubmed: 231628
Prostate. 2013 Nov;73(15):1636-50
pubmed: 23996639
J Endocrinol. 1989 Jun;121(3):419-24
pubmed: 2526845
Prostate. 2016 May;76(6):575-87
pubmed: 26841972
Exp Clin Endocrinol. 1988 Aug;91(3):311-8
pubmed: 2978021
Prostate Cancer Prostatic Dis. 2014 Jun;17(2):192-8
pubmed: 24637537
Cancer Res. 2008 Jun 1;68(11):4447-54
pubmed: 18519708
Transl Androl Urol. 2013 Sep;2(3):212-227
pubmed: 25379460
J Endocrinol. 2009 Jul;202(1):99-109
pubmed: 19403566
FEBS J. 2012 May;279(9):1584-93
pubmed: 21883931
Endocrinology. 1988 Dec;123(6):2675-82
pubmed: 2848682
Cancer Res. 2012 Dec 1;72(23):6142-52
pubmed: 22971343
J Endocrinol. 2006 Oct;191(1):301-8
pubmed: 17065412
Ann Surg. 1974 Jan;179(1):17-23
pubmed: 4817870
Prostate. 1987;10(4):313-24
pubmed: 3601809
Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):236-43
pubmed: 25772183
Clin Cancer Res. 2017 May 1;23(9):2301-2312
pubmed: 27993966
PLoS One. 2013 Nov 07;8(11):e77407
pubmed: 24244276
Diagn Pathol. 2012 Jun 20;7:42
pubmed: 22515559
Chem Biol Interact. 2015 Jun 5;234:332-8
pubmed: 25514466
Eur Urol. 2018 May;73(5):715-723
pubmed: 29258679
Mol Cell Endocrinol. 2016 Feb 15;422:182-191
pubmed: 26586211
Hum Pathol. 2003 Jul;34(7):646-53
pubmed: 12874759
Endocrinology. 1973 Jun;92(6):1579-81
pubmed: 4707253
Prostate. 2018 Feb;78(3):222-232
pubmed: 29194690
J Endocrinol. 2001 Nov;171(2):373-83
pubmed: 11691658
J Clin Oncol. 2012 Feb 20;30(6):637-43
pubmed: 22184395
Clin Adv Hematol Oncol. 2004 Nov;2(11):724-6
pubmed: 16163259
J Reprod Fertil. 1991 Nov;93(2):609-22
pubmed: 1787481
Nature. 2016 May 25;533(7604):547-51
pubmed: 27225130
Clin Cancer Res. 2012 Jul 1;18(13):3571-9
pubmed: 22753664
J Steroid Biochem Mol Biol. 2013 Nov;138:281-9
pubmed: 23851165
J Steroid Biochem Mol Biol. 2002 Nov;82(4-5):377-84
pubmed: 12589945
Steroids. 2011 Feb;76(3):301-8
pubmed: 21147140
Clin Cancer Res. 2014 Dec 15;20(24):6269-76
pubmed: 25336698
J Steroid Biochem. 1989 May;32(5):695-8
pubmed: 2525654
Clin Cancer Res. 2017 Aug 15;23(16):4592-4601
pubmed: 28389510
Sleep. 2010 Sep;33(9):1147-57
pubmed: 20857860
J Clin Endocrinol Metab. 1984 Sep;59(3):547-50
pubmed: 6235240
Am J Pathol. 2004 Jan;164(1):217-27
pubmed: 14695335
Cancer Manag Res. 2014 Jan 28;6:39-51
pubmed: 24501545
Clin Cancer Res. 2015 Mar 15;21(6):1273-80
pubmed: 25320358
Cancer Res. 2012 Jul 15;72(14):3457-62
pubmed: 22710436
J Steroid Biochem Mol Biol. 2015 Jul;151:66-73
pubmed: 25446886
Life Sci. 1992;50(12):857-61
pubmed: 1312193
Endocrinology. 2013 Mar;154(3):1190-201
pubmed: 23354096
Endocrinology. 2015 Jul;156(7):2492-502
pubmed: 25856427
J Endocrinol. 2006 Jul;190(1):47-57
pubmed: 16837610
J Androl. 2005 Sep-Oct;26(5):586-91
pubmed: 16088034
J Clin Oncol. 2013 Aug 1;31(22):2791-8
pubmed: 23816964
Prostate. 2017 May;77(6):654-671
pubmed: 28156002

Auteurs

Elahe A Mostaghel (EA)

Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington. emostagh@fredhutch.org.
Fred Hutchinson Cancer Research Center, Seattle, Washington.

Ailin Zhang (A)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Susana Hernandez (S)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Brett T Marck (BT)

Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington.

Xiaotun Zhang (X)

Department of Urology, University of Washington, Seattle, Washington.

Daniel Tamae (D)

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Heather E Biehl (HE)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Maria Tretiakova (M)

Department of Pathology, University of Washington, Seattle, Washington.

Jon Bartlett (J)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

John Burns (J)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Ruth Dumpit (R)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Lisa Ang (L)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Alvin M Matsumoto (AM)

Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington.

Trevor M Penning (TM)

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
ORCID: 0000-0002-3937-1066

Steven P Balk (SP)

Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Colm Morrissey (C)

Department of Urology, University of Washington, Seattle, Washington.

Eva Corey (E)

Department of Urology, University of Washington, Seattle, Washington.
ORCID: 0000-0002-9244-3807

Lawrence D True (LD)

Department of Pathology, University of Washington, Seattle, Washington.

Peter S Nelson (PS)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Hydroxysteroid dehydrogenases › 17-Hydroxysteroid dehydrogenases › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie des glandes endocrines › Surrénalectomie › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Hydroxyprostaglandine dehydrogenases › Aldo-keto reductase family 1 member C3 › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Eucaryotes › Animaux › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Progesterone reductase › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Tumeurs prostatiques résistantes à la castration › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs aux androgènes › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Steroid hydroxylases › Steroid 17-alpha-hydroxylase › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Intramolecular oxidoreductases › Carbon-carbon double bond isomerases › Steroid isomerases › Contribution of Adrenal Glands to Intratumor...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Contribution of Adrenal Glands to Intratumor...