Aberrant structural-functional coupling in adult cannabis users.
cannabis
connectome
functional connectivity
structural connectivity
structural-functional coupling
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
03
2018
revised:
09
08
2018
accepted:
11
08
2018
pubmed:
12
9
2018
medline:
9
4
2020
entrez:
12
9
2018
Statut:
ppublish
Résumé
Cellular studies indicate that endocannabinoid type-1 retrograde signaling plays a major role in synaptic plasticity. Disruption of these processes by delta-9-tetrahydrocannabinol (THC) could produce alterations either in structural and functional brain connectivity or in their association in cannabis (CB) users. Graph theoretic structural and functional networks were generated with diffusion tensor imaging and resting-state functional imaging in 37 current CB users and 31 healthy non-users. The primary outcome measures were coupling between structural and functional connectivity, global network characteristics, association between the coupling and network properties, and measures of rich-club organization. Structural-functional (SC-FC) coupling was globally preserved showing a positive association in current CB users. However, the users had disrupted associations between SC-FC coupling and network topological characteristics, most perturbed for shorter connections implying region-specific disruption by CB use. Rich-club analysis revealed impaired SC-FC coupling in the hippocampus and caudate of users. This study provides evidence of the abnormal SC-FC association in CB users. The effect was predominant in shorter connections of the brain network, suggesting that the impact of CB use or predispositional factors may be most apparent in local interconnections. Notably, the hippocampus and caudate specifically showed aberrant structural and functional coupling. These structures have high CB1 receptor density and may also be associated with changes in learning and habit formation that occur with chronic cannabis use.
Identifiants
pubmed: 30203892
doi: 10.1002/hbm.24369
pmc: PMC6289814
mid: NIHMS992429
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
252-261Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA035493
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH074983
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024628
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT009036
Pays : United States
Organisme : National Institutes of Health, Grant/Award Number: UL1TR002529; National Science Foundation, Grant/Award Number: 1342962; National Center for Complementary and Integrative Health, Grant/Award Number: R01AT009036; National Institute of Mental Health, Grant/Award Number: 2R01MH074983; National Institute on Drug Abuse, Grant/Award Numbers: T32DA024628, 5R21DA035493
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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