Myorelaxant Activity of essential oil from Origanum majorana L. on rat and rabbit.
Antispasmodic
Essential oil
Intestine
Myorelaxant
Origanum majorana L.
Rabbit
Rat
Journal
Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
received:
26
05
2018
revised:
29
08
2018
accepted:
30
08
2018
pubmed:
12
9
2018
medline:
26
12
2018
entrez:
12
9
2018
Statut:
ppublish
Résumé
Origanum majorana L. (Lamiaceae) was usually used in Moroccan folk medicine to treat infantile colic and abdominal discomfort. The essential oil from the aerial part of the dry Origanum majorana L. (EOOM) was obtained through hydro distillation and analyzed by gas chromatography/mass spectrometry (GC/MS). The effect of EOOM on muscle relaxation was measured on rabbit and rat intestinal smooth muscle mounted in an isotonic transducer. 1) The main compounds obtained from the aqueous extract of this plant were alpha Terpineol, L-terpinen-4-ol and Beta.-Linalool. 2) EOOM inhibited in a concentration-dependent manner spontaneous contraction of rabbit jejunum, with an IC the present result indicates that essential oil of Origanum majorana L. exhibit an effect on intestinal relaxation in vitro. This effect further validates the traditional use of Origanum majorana L. to treat infantile colic and abdominal discomfort.
Identifiants
pubmed: 30205180
pii: S0378-8741(18)31916-0
doi: 10.1016/j.jep.2018.08.036
pii:
doi:
Substances chimiques
Oils, Volatile
0
Parasympatholytics
0
Terpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-49Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.