Multivariable evaluation of maternal hemodynamic profile in pregnancy complicated by fetal growth restriction: prospective study.
Adult
Cardiac Output
/ physiology
Diastole
/ physiology
Echocardiography
/ methods
Female
Fetal Growth Retardation
/ epidemiology
Gestational Age
Hemodynamics
/ physiology
Humans
Hypertension, Pregnancy-Induced
/ drug therapy
Middle Aged
Middle Cerebral Artery
/ diagnostic imaging
Outcome Assessment, Health Care
Perinatal Mortality
/ trends
Pre-Eclampsia
/ epidemiology
Pregnancy
Pregnancy Complications
/ epidemiology
Prospective Studies
Ultrasonography, Doppler, Color
/ methods
Umbilical Arteries
/ diagnostic imaging
Uterine Artery
/ diagnostic imaging
Vascular Resistance
/ physiology
Ventricular Remodeling
/ physiology
IUGR
echocardiographic parameters; FGR; hemodynamics
hypertensive disorders of pregnancy
maternal echocardiography
multivariate analysis
Journal
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
04
05
2018
revised:
20
07
2018
accepted:
24
08
2018
pubmed:
13
9
2018
medline:
6
5
2020
entrez:
13
9
2018
Statut:
ppublish
Résumé
To evaluate the association between fetal growth restriction (FGR) and maternal hemodynamic parameters using multivariable analysis, adjusting for major confounding factors, such as hypertensive disorders of pregnancy (pre-eclampsia and gestational hypertension). A prospective cohort study was conducted between January 2013 and April 2016. Two cohorts of patients were recruited, between 24 and 39 weeks of gestation, in a high-risk outpatient setting. These cohorts comprised 49 appropriate-for-gestational-age singleton fetuses and 93 that were FGR (abdominal circumference (AC) at recruitment in the second half of pregnancy ≤ 10 In the multivariable analysis, after adjustment for hypertensive disorders of pregnancy and smoking, FGR was associated with a 14% increase in maternal total vascular resistance, 16% reduction in cardiac output, 13% reduction in left ventricular mass and 11% reduction in heart rate; similar results were observed for the corresponding indexed parameters. Hypertensive disorders of pregnancy in the absence of FGR were associated with a 25% increase in total vascular resistance, 16% increase in left ventricular mass and 14% reduction in diastolic function; similar results were observed for the corresponding indexed parameters. FGR is significantly and independently associated with several maternal hemodynamic parameters, even after adjustment for major confounding factors, such as hypertensive disorders of pregnancy. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
Types de publication
Comparative Study
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
732-739Subventions
Organisme : Associazione Studio Malformazioni (ASM)
Informations de copyright
Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
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