Angina bullosa haemorrhagica-like lesions in pemphigus vulgaris.
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents
/ therapeutic use
Blister
/ pathology
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Mouth Diseases
/ drug therapy
Mouth Mucosa
/ pathology
Oral Hemorrhage
/ drug therapy
Pemphigus
/ drug therapy
Prednisolone
/ therapeutic use
Young Adult
angina bullosa haemorrhagica
autoimmune blistering skin disorder
oral blisters
pemphigus vulgaris
Journal
The Australasian journal of dermatology
ISSN: 1440-0960
Titre abrégé: Australas J Dermatol
Pays: Australia
ID NLM: 0135232
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
15
01
2018
accepted:
05
08
2018
pubmed:
15
9
2018
medline:
18
12
2019
entrez:
15
9
2018
Statut:
ppublish
Résumé
The aim of this study was to describe a previously unreported association of oral pemphigus vulgaris with short-lived blood-filled painless blisters resembling angina bullosa haemorrhagica (ABH). A cross-sectional study of consecutive patients with Pemphigus vulgaris. All patients were examined for the presence of ABH-like lesions, and demographic, clinical and histopathological data were collected. Histopathological examination was performed when feasible. A total of 318 with pemphigus vulgaris were included (63.5% female, mean age: 46 years). ABH-like lesions were present in 82 (25.8%) patients, commonly observed in the buccal mucosa (47, 57.3%) followed by the palate (15, 18.3%). All patients had normal platelet counts with no evidence of bleeding diathesis. Biopsies of the ABH-like lesions showed suprabasal clefts in four of six samples. ABH-like lesions were significantly associated with partial remission of pemphigus vulgaris (47.5%, P = 0.002) and the use of intraoral steroids (P = 0.001, odds ratio: 5.9 [95% confidence interval: 2.5-13.6]). ABH-like lesions may represent a transient or abortive form of oral pemphigus vulgaris and tend to have a benign and self-limiting nature.
Sections du résumé
BACKGROUND/OBJECTIVES
OBJECTIVE
The aim of this study was to describe a previously unreported association of oral pemphigus vulgaris with short-lived blood-filled painless blisters resembling angina bullosa haemorrhagica (ABH).
METHODS
METHODS
A cross-sectional study of consecutive patients with Pemphigus vulgaris. All patients were examined for the presence of ABH-like lesions, and demographic, clinical and histopathological data were collected. Histopathological examination was performed when feasible.
RESULTS
RESULTS
A total of 318 with pemphigus vulgaris were included (63.5% female, mean age: 46 years). ABH-like lesions were present in 82 (25.8%) patients, commonly observed in the buccal mucosa (47, 57.3%) followed by the palate (15, 18.3%). All patients had normal platelet counts with no evidence of bleeding diathesis. Biopsies of the ABH-like lesions showed suprabasal clefts in four of six samples. ABH-like lesions were significantly associated with partial remission of pemphigus vulgaris (47.5%, P = 0.002) and the use of intraoral steroids (P = 0.001, odds ratio: 5.9 [95% confidence interval: 2.5-13.6]).
CONCLUSION
CONCLUSIONS
ABH-like lesions may represent a transient or abortive form of oral pemphigus vulgaris and tend to have a benign and self-limiting nature.
Substances chimiques
Anti-Inflammatory Agents
0
Prednisolone
9PHQ9Y1OLM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e105-e108Informations de copyright
© 2018 The Australasian College of Dermatologists.