High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats.
Brain
HMGB1
Hypoxia
Ischemia
Neonate
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
12
2017
revised:
13
07
2018
accepted:
10
09
2018
pubmed:
16
9
2018
medline:
11
4
2019
entrez:
16
9
2018
Statut:
ppublish
Résumé
Inflammation contributes to neonatal brain injury. Pro-inflammatory cytokines represent key inflammatory meditators in neonatal hypoxic-ischemic (HI) brain injury. The high mobility group box-1 (HMGB1) protein is a nuclear protein with pro-inflammatory cytokine properties when it is translocated from the nucleus and released extracellularly after stroke in adult rodents. We have previously shown that HMGB1 is translocated from the nucleus to cytosolic compartment after ischemic brain injury in fetal sheep. In the current study, we utilized the Rice-Vannucci model to investigate the time course of HMGB1 translocation and release after HI injury in neonatal rats. HMGB1 was located in cellular nuclei of brains from sham control rats. Nuclear to cytoplasmic translocation of HMGB1 was detected in the ipsilateral-HI hemisphere as early as zero h after HI, and released extracellularly as early as 6 h after HI. Immunohistochemical double staining detected HMGB1 translocation mainly in neurons along with release from apoptotic cells after HI. Serum HMGB1 increased at 3 h and decreased by 24 h after HI. In addition, rat brains exposed to hypoxic injury alone also exhibited time dependent HMGB1 translocation at 3, 12 and 48 h after hypoxia. Consequently, HMGB1 responds similarly after HI injury in the brains of neonatal and adult subjects. We conclude that HMGB1 is sensitive early indicator of neonatal HI and hypoxic brain injury.
Identifiants
pubmed: 30217406
pii: S0014-4886(18)30458-8
doi: 10.1016/j.expneurol.2018.09.007
pmc: PMC6261802
mid: NIHMS1507326
pii:
doi:
Substances chimiques
Biomarkers
0
HMGB1 Protein
0
Hbp1 protein, rat
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-14Subventions
Organisme : American Heart Association-American Stroke Association
ID : 13POST16860015
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS096525
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD057100
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103537
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS095130
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR018728
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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