Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARγ.

CD36 Antigens / metabolism Cell Differentiation / drug effects Dibutyl Phthalate / pharmacology Humans Macrophages / cytology Monocytes / cytology PPAR gamma / agonists THP-1 Cells Tetradecanoylphorbol Acetate
CD36 Differentiation Macrophage PPARγ Phthalate di-n-butyl phthalate

Journal

Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 17 04 2018
revised: 14 08 2018
accepted: 10 09 2018
pubmed: 16 9 2018
medline: 15 1 2019
entrez: 16 9 2018
Statut: ppublish

Résumé

The present study examined the effects of di-n-butyl phthalate (DBP) on phorbol myristate acetate (PMA)-induced macrophage differentiation of THP-1 monocytes, determined by morphological classification and flow cytometry. Focusing on the expression of the surface marker CD36, the potential role of peroxisome proliferator-activated receptor gamma (PPARγ) was examined using various PPARγ agonists and antagonists. As the PPARγ ligand-binding domain contains multiple ligand-binding sites (LBS), agonist and antagonists targeting the different sites were used. DBP accelerated PMA-induced morphological changes and increased expression of CD36, although to a lesser degree than the PPARγ agonists rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J

Identifiants

DOI: 10.1016/j.tiv.2018.09.004 PMID: 30218697
pubmed: 30218697
pii: S0887-2333(18)30547-2
doi: 10.1016/j.tiv.2018.09.004
pii:
doi:

Substances chimiques

CD36 Antigens 0
CD36 protein, human 0
PPAR gamma 0
Dibutyl Phthalate 2286E5R2KE
Tetradecanoylphorbol Acetate NI40JAQ945

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

168-177

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Vegard Sæter Grytting (VS)

Department of Air Pollution and Noise, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403 Oslo, Norway. Electronic address: vegard.saeter.grytting@fhi.no.

Bergitte Pearl Olderbø (BP)

Nordic Institute of Dental Materials, Sognsveien 70A, N-0855 Oslo, Norway.

Jørn A Holme (JA)

Department of Air Pollution and Noise, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403 Oslo, Norway.

Jan Tore Samuelsen (JT)

Nordic Institute of Dental Materials, Sognsveien 70A, N-0855 Oslo, Norway.

Anita Solhaug (A)

Norwegian Veterinary Institute, Toxinology Research Group, P.O. Box 750, Sentrum, N-0106 Oslo, Norway.

Rune Becher (R)

Department of Air Pollution and Noise, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403 Oslo, Norway.

Anette Kocbach Bølling (AK)

Department of Air Pollution and Noise, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403 Oslo, Norway.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Récepteurs éboueurs › Récepteurs éboueurs de classe B › Antigènes CD36 › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acides phtaliques › Phtalate de dibutyle › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › Di-n-butyl phthalate modifies PMA-induced...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Phorbols › Esters de phorbol › 12-Myristate-13-acétate de phorbol › Di-n-butyl phthalate modifies PMA-induced...