On the role of the immunoproteasome in transplant rejection.
Antigen presentation
Antigen processing
Immunoproteasome
Proteasome
Transplantation
Journal
Immunogenetics
ISSN: 1432-1211
Titre abrégé: Immunogenetics
Pays: United States
ID NLM: 0420404
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
17
07
2018
accepted:
04
09
2018
pubmed:
17
9
2018
medline:
10
8
2019
entrez:
17
9
2018
Statut:
ppublish
Résumé
The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated cancer formation, and transplantation. Immunoproteasome inhibition prevents activation and proliferation of lymphocytes, lowers MHC class I cell surface expression, reduces the expression of cytokines of activated immune cells, and curtails T helper 1 and 17 cell differentiation. This might explain the in vivo efficacy of immunoproteasome inhibition in different pre-clinical disease models for autoimmunity, cancer, and transplantation. In this review, we summarize the effect of immunoproteasome inhibition in different animal models for transplantation.
Identifiants
pubmed: 30220008
doi: 10.1007/s00251-018-1084-0
pii: 10.1007/s00251-018-1084-0
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Proteasome Inhibitors
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
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