Evolutionary considerations on 5-HT
Evolution
Proteasome
Receptor
Serotonin
Vertebrates
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
05
09
2018
revised:
13
09
2018
accepted:
13
09
2018
pubmed:
18
9
2018
medline:
14
5
2019
entrez:
18
9
2018
Statut:
ppublish
Résumé
Serotonin is a neurotransmitter widely conserved from ancient organisms lacking nervous systems through man, and its presence precedes the appearance of nervous systems on both developmental and evolutionary time scales. Serotonin receptor subtypes diversified approximately at the time period during which vertebrates diverged from invertebrates. The biological and clinical importance of serotonin receptors, may benefit from studies on their evolution. Although potentially informative about their pathophysiological functions, reviews on this topic are sparse. Several observations support basic functions mediated by serotonin, both in periphery and central nervous system. In particular, 5-HT
Identifiants
pubmed: 30223085
pii: S1043-6618(18)31325-2
doi: 10.1016/j.phrs.2018.09.014
pii:
doi:
Substances chimiques
PSMD1 protein, human
0
Receptors, Serotonin
0
Serotonin
333DO1RDJY
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-20Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.