Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers.
Animals
Antineoplastic Combined Chemotherapy Protocols
/ pharmacology
Apoptosis
/ drug effects
Autophagy
/ drug effects
Carboplatin
/ administration & dosage
Cell Line, Tumor
Drug Resistance, Neoplasm
/ drug effects
Drug Synergism
Enzyme Inhibitors
/ pharmacology
Female
Glycolysis
/ drug effects
Humans
Lipid Droplets
/ drug effects
Mice, Nude
Ovarian Neoplasms
/ drug therapy
Paclitaxel
/ administration & dosage
Phosphofructokinase-2
/ antagonists & inhibitors
Pyridines
/ pharmacology
Quinolines
/ pharmacology
Xenograft Model Antitumor Assays
Chemoresistance
PFKFB3
lipid droplet
lipophagy
ovarian and cervical cancer
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
08
01
2018
revised:
27
06
2018
accepted:
01
08
2018
pubmed:
19
9
2018
medline:
16
4
2019
entrez:
19
9
2018
Statut:
ppublish
Résumé
Metabolic alterations are increasingly recognized as important novel anti-cancer targets. Among several regulators of metabolic alterations, fructose 2,6 bisphosphate (F2,6BP) is a critical glycolytic regulator. Inhibition of the active form of PFKFB3
Identifiants
pubmed: 30226266
doi: 10.1002/ijc.31868
pmc: PMC6261695
mid: NIHMS993076
doi:
Substances chimiques
Enzyme Inhibitors
0
PFK158
0
Pyridines
0
Quinolines
0
Carboplatin
BG3F62OND5
PFKFB3 protein, human
EC 2.7.1.105
Phosphofructokinase-2
EC 2.7.1.105
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
178-189Subventions
Organisme : NCI NIH HHS
ID : P50 CA136393
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA106954
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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