Identification of Predictors of Recurrence in Patients with Lower Rectal Cancer Undergoing Neoadjuvant Chemotherapy: A Direct Comparison of Short-Course and Long-Course Chemoradiotherapy.
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Chemoradiotherapy
Chemotherapy, Adjuvant
Disease-Free Survival
Female
Fluorouracil
/ administration & dosage
Humans
Leucovorin
/ administration & dosage
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Recurrence, Local
/ pathology
Neoplasm Staging
Rectal Neoplasms
/ drug therapy
Retrospective Studies
Survival Rate
Tegafur
/ administration & dosage
Uracil
/ administration & dosage
Chemoradiation
Downstaging
Prognosis
Rectal cancer
Tumor regression
Journal
Oncology
ISSN: 1423-0232
Titre abrégé: Oncology
Pays: Switzerland
ID NLM: 0135054
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
07
2018
accepted:
01
08
2018
pubmed:
19
9
2018
medline:
6
2
2019
entrez:
19
9
2018
Statut:
ppublish
Résumé
This study aimed to investigate clinicopathological responses and oncological outcome in patients receiving short- or long-course chemoradiotherapy (CRT) and to assess the predictive factor for recurrence in each treatment. A total of 118 rectal cancer patients receiving preoperative CRT were enrolled. Clinicopathological responses and oncological outcome in patients receiving short- or long-course CRT were investigated. Despite there being no significant differences in the prognosis of disease-free survival (DFS) based on TNM stage classification in patients receiving long-course CRT, patients with advanced stage demonstrated poor DFS after short-course CRT. The presence of lymph node metastasis was a predictor of poor DFS in short-course CRT, whereas poor pathological response was a predictor of recurrence in long-course CRT. Distinct predictors of recurrence depending on the CRT course might be needed to discriminate candidates from rectal cancer patients receiving preoperative CRT who might benefit from more intensive adjuvant therapy after surgery.
Identifiants
pubmed: 30227430
pii: 000492617
doi: 10.1159/000492617
doi:
Substances chimiques
Tegafur
1548R74NSZ
Uracil
56HH86ZVCT
Leucovorin
Q573I9DVLP
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-78Informations de copyright
© 2018 S. Karger AG, Basel.