Correlating new directional measures of myelin and axonal integrity in T2-weighted MRI with quantitative histology in multiple sclerosis.
Axons
/ pathology
Brain
/ diagnostic imaging
Fourier Analysis
Histological Techniques
/ methods
Humans
Image Processing, Computer-Assisted
/ methods
Magnetic Resonance Imaging
Multiple Sclerosis
/ diagnostic imaging
Myelin Sheath
/ pathology
Signal Processing, Computer-Assisted
White Matter
/ diagnostic imaging
Axons
Brain white matter
Clinical MRI
Diffusely abnormal white matter
Fourier transform power spectrum
Lesions
Multiple sclerosis
Myelin
Normal appearing white matter
Quantitative histology
Tissue alignment
Journal
Journal of neuroscience methods
ISSN: 1872-678X
Titre abrégé: J Neurosci Methods
Pays: Netherlands
ID NLM: 7905558
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
14
06
2018
revised:
17
09
2018
accepted:
17
09
2018
pubmed:
22
9
2018
medline:
26
3
2020
entrez:
22
9
2018
Statut:
ppublish
Résumé
Imaging measurement of structure alignment has shown increasing importance in determining tissue properties. It is not known if a similar ability for characterizing neuropathology exists. This study aimed to validate a new alignment-assessing method for measuring myelin and axonal properties using quantitative histological metrics. The new method involved analysis of the Fourier transform (FT) power spectrum in standard magnetic resonance imaging (MRI). T There were significant differences in orientation metrics between tissue types in both MRI and histology, and MRI measurements correlated strongly with histological indices. Moreover, the joint effect of myelin and axonal entropy explained over 95% of the variance of MRI angular entropy. There is no established method for characterizing myelin and axonal pathology using standard MRI. Advanced MRI methods have the potential to do this but are still in research development and are not yet routinely acquired in clinical practice. Alignment measurement using clinical MRI scans may become a valuable new method for characterizing myelin and axonal properties in MS patients.
Sections du résumé
BACKGROUND
Imaging measurement of structure alignment has shown increasing importance in determining tissue properties. It is not known if a similar ability for characterizing neuropathology exists.
NEW METHODS
This study aimed to validate a new alignment-assessing method for measuring myelin and axonal properties using quantitative histological metrics. The new method involved analysis of the Fourier transform (FT) power spectrum in standard magnetic resonance imaging (MRI). T
RESULTS
There were significant differences in orientation metrics between tissue types in both MRI and histology, and MRI measurements correlated strongly with histological indices. Moreover, the joint effect of myelin and axonal entropy explained over 95% of the variance of MRI angular entropy.
COMPARISON WITH EXISTING METHOD
There is no established method for characterizing myelin and axonal pathology using standard MRI. Advanced MRI methods have the potential to do this but are still in research development and are not yet routinely acquired in clinical practice.
CONCLUSIONS
Alignment measurement using clinical MRI scans may become a valuable new method for characterizing myelin and axonal properties in MS patients.
Identifiants
pubmed: 30240805
pii: S0165-0270(18)30287-5
doi: 10.1016/j.jneumeth.2018.09.020
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-376Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.