Cellular Interactions in the Intestinal Stem Cell Niche.
Animals
Cell Communication
Colorectal Neoplasms
/ metabolism
Epithelial Cells
/ metabolism
Epithelial-Mesenchymal Transition
Fibrosis
Humans
Inflammatory Bowel Diseases
/ metabolism
Intestinal Mucosa
/ metabolism
Myofibroblasts
/ metabolism
Neoplastic Stem Cells
/ metabolism
Phenotype
Signal Transduction
Stem Cell Niche
Stem Cells
/ metabolism
Inflammatory bowel disease
Intestinal stem cells
Mesenchymal–epithelial cross-talk
Myofibroblasts
Stem cell niche
Journal
Archivum immunologiae et therapiae experimentalis
ISSN: 1661-4917
Titre abrégé: Arch Immunol Ther Exp (Warsz)
Pays: Switzerland
ID NLM: 0114365
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
24
04
2018
accepted:
06
07
2018
pubmed:
23
9
2018
medline:
14
6
2019
entrez:
23
9
2018
Statut:
ppublish
Résumé
Epithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Here, we discuss the role of intestinal myofibroblasts, α-smooth muscle actin-positive stromal (mesenchymal) cells, as an important regulatory part of the intestinal stem cell niche. Better understanding of the cross-talk between myofibroblasts and the epithelium in the intestine has implications for advances in regenerative medicine, and improved therapeutic strategies for inflammatory bowel disease, intestinal fibrosis and colorectal cancer.
Identifiants
pubmed: 30242440
doi: 10.1007/s00005-018-0524-8
pii: 10.1007/s00005-018-0524-8
pmc: PMC6434028
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-26Subventions
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : K/ZDS/005454
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