Retinal Ganglion Cell Replacement: Current Status and Challenges Ahead.
Retinal ganglion cells
cell replacement
retinal organoids
stem cells
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Titre abrégé: Dev Dyn
Pays: United States
ID NLM: 9201927
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
08
08
2018
revised:
11
09
2018
accepted:
11
09
2018
pubmed:
23
9
2018
medline:
14
8
2019
entrez:
23
9
2018
Statut:
ppublish
Résumé
The neurons of the retina can be affected by a wide variety of inherited or environmental degenerations that can lead to vision loss and even blindness. Retinal ganglion cell (RGC) degeneration is the hallmark of glaucoma and other optic neuropathies that affect millions of people worldwide. Numerous strategies are being trialed to replace lost neurons in different degeneration models, and in recent years, stem cell technologies have opened promising avenues to obtain donor cells for retinal repair. Stem cell-based transplantation has been most frequently used for the replacement of rod photoreceptors, but the same tools could potentially be used for other retinal cell types, including RGCs. However, RGCs are not abundant in stem cell-derived cultures, and in contrast to the short-distance wiring of photoreceptors, RGC axons take a long and intricate journey to connect with numerous brain nuclei. Hence, a number of challenges still remain, such as the ability to scale up the production of RGCs and a reliable and functional integration into the adult diseased retina upon transplantation. In this review, we discuss the recent advancements in the development of replacement therapies for RGC degenerations and the challenges that we need to overcome before these technologies can be applied to the clinic. Developmental Dynamics 248:118-128, 2019. © 2018 Wiley Periodicals, Inc.
Identifiants
pubmed: 30242792
doi: 10.1002/dvdy.24672
pmc: PMC7141838
mid: NIHMS1022554
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Pagination
118-128Subventions
Organisme : NEI NIH HHS
ID : P30 EY012576
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026942
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY015387
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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