White matter - emotion processing activity relationships in youth offspring of bipolar parents.
Adolescent
Amygdala
/ pathology
Anisotropy
Bipolar Disorder
Case-Control Studies
Child
Child of Impaired Parents
/ psychology
Diffusion Tensor Imaging
Emotions
/ physiology
Facial Expression
Female
Frontal Lobe
/ pathology
Gyrus Cinguli
/ pathology
Humans
Magnetic Resonance Imaging
Male
Parents
/ psychology
Prefrontal Cortex
/ pathology
White Matter
/ pathology
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
09
03
2018
revised:
31
07
2018
accepted:
09
09
2018
pubmed:
23
9
2018
medline:
1
3
2019
entrez:
23
9
2018
Statut:
ppublish
Résumé
Early detection of Bipolar Disorder (BD) is critical for targeting interventions to delay or prevent illness onset. Yet, the absence of objective BD biomarkers makes accurately identifying at-risk youth difficult. In this study, we examined how relationships between white matter tract (WMT) structure and activity in emotion processing neural circuitry differentiate youth at risk for BD from youth at risk for other psychiatric disorders. Offspring (ages 8-17) of parents with BD (OBP, n = 32), offspring of comparison parents with non-BD psychopathology (OCP, n = 30), and offspring of healthy parents (OHP, n = 24) underwent diffusion tensor and functional magnetic resonance imaging while performing an emotional face processing task. Penalized and multiple regression analyses included GROUP(OBP,OCP)xWMT interactions as main independent variables, and emotion processing activity as dependent variables, to determine significant group differences in WMT-activity relationships. 8 GROUPxWMT interaction variables contributed to 16.5% of the variance in amygdala and prefrontal cortical activity to happy faces. Of these, significant group differences in slopes (inverse for OBP, positive for OCP) existed for the relationship between forceps minor radial diffusivity and rostral anterior cingulate activity (p = 0.014). Slopes remained significantly different in unmedicated youth without psychiatric disorders (p = 0.017) and were moderated by affective lability symptoms (F(1,29) = 5.566, p = 0.036). Relatively small sample sizes were included. Forceps minor radial diffusivity-rostral anterior cingulate activity relationships may reflect underlying neuropathological processes that contribute to affectively labile youth at risk for BD and may help differentiate them from youth at risk for other psychiatric disorders.
Sections du résumé
BACKGROUND
Early detection of Bipolar Disorder (BD) is critical for targeting interventions to delay or prevent illness onset. Yet, the absence of objective BD biomarkers makes accurately identifying at-risk youth difficult. In this study, we examined how relationships between white matter tract (WMT) structure and activity in emotion processing neural circuitry differentiate youth at risk for BD from youth at risk for other psychiatric disorders.
METHODS
Offspring (ages 8-17) of parents with BD (OBP, n = 32), offspring of comparison parents with non-BD psychopathology (OCP, n = 30), and offspring of healthy parents (OHP, n = 24) underwent diffusion tensor and functional magnetic resonance imaging while performing an emotional face processing task. Penalized and multiple regression analyses included GROUP(OBP,OCP)xWMT interactions as main independent variables, and emotion processing activity as dependent variables, to determine significant group differences in WMT-activity relationships.
RESULTS
8 GROUPxWMT interaction variables contributed to 16.5% of the variance in amygdala and prefrontal cortical activity to happy faces. Of these, significant group differences in slopes (inverse for OBP, positive for OCP) existed for the relationship between forceps minor radial diffusivity and rostral anterior cingulate activity (p = 0.014). Slopes remained significantly different in unmedicated youth without psychiatric disorders (p = 0.017) and were moderated by affective lability symptoms (F(1,29) = 5.566, p = 0.036).
LIMITATIONS
Relatively small sample sizes were included.
CONCLUSIONS
Forceps minor radial diffusivity-rostral anterior cingulate activity relationships may reflect underlying neuropathological processes that contribute to affectively labile youth at risk for BD and may help differentiate them from youth at risk for other psychiatric disorders.
Identifiants
pubmed: 30243195
pii: S0165-0327(18)30361-6
doi: 10.1016/j.jad.2018.09.010
pmc: PMC6476540
mid: NIHMS1022719
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
153-164Subventions
Organisme : NIMH NIH HHS
ID : F30 MH111102
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH060952
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001858
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier B.V.
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