A Meta-analysis of Prophylaxis of Surgical Site Infections with Topical Application of Povidone Iodine Before Primary Closure.
Journal
World journal of surgery
ISSN: 1432-2323
Titre abrégé: World J Surg
Pays: United States
ID NLM: 7704052
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
24
9
2018
medline:
14
6
2019
entrez:
24
9
2018
Statut:
ppublish
Résumé
Povidone iodine (PVI) is a widely used antiseptic solution among surgeons. A meta-analysis based on randomized controlled trials (RCTs) was conducted to establish whether application of PVI before wound closure could reduce surgical site infection (SSI) rates. Systematic review of MEDLINE/PubMed, Scopus, CINAHL, and Web of Science databases from inception to September 2017, with no language restrictions. Only RCTs were retrieved. The primary outcome was the SSI rate. Meta-analysis was complemented with trial sequential analysis (TSA). A total of 7601 patients collected from 16 RCTs were analyzed. A reduction in overall SSI rate was found (RR 0.64, 95% CI 0.48-0.85, P = 0.002, I There is no conclusive evidence for a strong recommendation of topical PVI before wound closure to prevent SSI.
Sections du résumé
BACKGROUND
BACKGROUND
Povidone iodine (PVI) is a widely used antiseptic solution among surgeons. A meta-analysis based on randomized controlled trials (RCTs) was conducted to establish whether application of PVI before wound closure could reduce surgical site infection (SSI) rates.
METHODS
METHODS
Systematic review of MEDLINE/PubMed, Scopus, CINAHL, and Web of Science databases from inception to September 2017, with no language restrictions. Only RCTs were retrieved. The primary outcome was the SSI rate. Meta-analysis was complemented with trial sequential analysis (TSA).
RESULTS
RESULTS
A total of 7601 patients collected from 16 RCTs were analyzed. A reduction in overall SSI rate was found (RR 0.64, 95% CI 0.48-0.85, P = 0.002, I
CONCLUSIONS
CONCLUSIONS
There is no conclusive evidence for a strong recommendation of topical PVI before wound closure to prevent SSI.
Identifiants
pubmed: 30244376
doi: 10.1007/s00268-018-4798-0
pii: 10.1007/s00268-018-4798-0
doi:
Substances chimiques
Anti-Infective Agents, Local
0
Povidone-Iodine
85H0HZU99M
Iodine
9679TC07X4
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
374-384Références
Infect Control Hosp Epidemiol. 1999 Apr;20(4):250-78; quiz 279-80
pubmed: 10219875
Br J Surg. 1975 Apr;62(4):292-4
pubmed: 1093604
Appl Nurs Res. 2002 Aug;15(3):197-8
pubmed: 12173172
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120
Int J Dermatol. 1992 May;31(5):359-60
pubmed: 1587669
J Bone Joint Surg Am. 2005 Jul;87(7):1415-22
pubmed: 15995106
Spine (Phila Pa 1976). 2005 Aug 1;30(15):1689-93
pubmed: 16094267
Eur Spine J. 2006 Jun;15(6):1005-14
pubmed: 16133077
Dermatology. 2006;212 Suppl 1:53-7
pubmed: 16490976
Am J Med. 1991 Sep 16;91(3B):152S-157S
pubmed: 1656747
Ann Thorac Surg. 1992 Feb;53(2):301-5
pubmed: 1731672
Acta Chir Orthop Traumatol Cech. 2008 Apr;75(2):106-9
pubmed: 18454914
J Clin Epidemiol. 2009 Oct;62(10):e1-34
pubmed: 19631507
Arch Intern Med. 2010 May 10;170(9):749-50
pubmed: 20458080
J Int Med Res. 2010 Jul-Aug;38(4):1287-93
pubmed: 20926001
J Hosp Infect. 2011 Apr;77(4):363-4
pubmed: 21257229
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
PLoS One. 2011;6(10):e25491
pubmed: 22028777
ANZ J Surg. 2013 Nov;83(11):844-6
pubmed: 23360528
Mayo Clin Proc. 2013 Aug;88(8):790-8
pubmed: 23871230
BMJ. 2015 Jun 03;350:h2463
pubmed: 26041754
Aust N Z J Obstet Gynaecol. 2016 Jun;56(3):301-6
pubmed: 26847398
Injury. 2016 Sep;47(9):1913-8
pubmed: 27269416
J Hosp Infect. 2016 Aug;93(4):319-22
pubmed: 27388057
Lancet Infect Dis. 2016 Dec;16(12):e276-e287
pubmed: 27816413
Lancet Infect Dis. 2016 Dec;16(12):e288-e303
pubmed: 27816414
Cochrane Database Syst Rev. 2016 Nov 07;11:CD011426
pubmed: 27819748
Surg Infect (Larchmt). 2017 May/Jun;18(4):508-519
pubmed: 28448203
J Hosp Infect. 1985 Mar;6 Suppl A:103-14
pubmed: 2860153
Ann R Coll Surg Engl. 1988 Sep;70(5):313-6
pubmed: 3056208
Br J Surg. 1978 Feb;65(2):89-91
pubmed: 342043
Br J Surg. 1986 Dec;73(12):958-60
pubmed: 3790957
Surg Gynecol Obstet. 1979 Feb;148(2):227-31
pubmed: 419426
Surg Forum. 1977;28:48-51
pubmed: 617510
Ann R Coll Surg Engl. 1983 Nov;65(6):397-9
pubmed: 6357036
Surg Gynecol Obstet. 1983 Nov;157(5):426-30
pubmed: 6635913
Br J Surg. 1981 Mar;68(3):185-9
pubmed: 7008894
Injury. 1980 Sep;12(2):104-6
pubmed: 7009430
Br J Surg. 1981 May;68(5):310-3
pubmed: 7013895
Ir Med J. 1982 Mar;75(3):96
pubmed: 7042641
Surg Gynecol Obstet. 1982 Aug;155(2):221-4
pubmed: 7048591
Am J Surg. 1981 Sep;142(3):393-7
pubmed: 7283035
Surg Clin North Am. 1980 Feb;60(1):27-40
pubmed: 7361226
Lancet. 1978 Apr 8;1(8067):769
pubmed: 76769
Br J Surg. 1975 Oct;62(10):792-9
pubmed: 811302