GPR15
Biomarkers
Cytokines
/ metabolism
Disease Susceptibility
Female
Gene Expression
Humans
Immunophenotyping
Lymphocyte Count
Magnetic Resonance Imaging
Male
Multiple Sclerosis
/ diagnosis
Receptors, G-Protein-Coupled
/ genetics
Receptors, Peptide
/ genetics
Smokers
T-Lymphocyte Subsets
/ immunology
Th17 Cells
/ immunology
CD4
CSF
GPR15
Multiple sclerosis
RRMS
Smoking
Journal
Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
06
2018
revised:
07
09
2018
accepted:
12
09
2018
pubmed:
25
9
2018
medline:
27
5
2020
entrez:
25
9
2018
Statut:
ppublish
Résumé
Smoking is a risk factor for the development and progression of multiple sclerosis (MS); however, the pathogenic effects of smoking are poorly understood. We studied the smoking-associated chemokine receptor-like molecule GPR15 in relation to relapsing-remitting MS (RRMS). Using microarray analyses and qPCR we found elevated GPR15 in blood cells from smokers, and increased GPR15 expression in RRMS. By flow cytometry we detected increased frequencies of GPR15 expressing T and B cells in smokers, but no difference between patients with RRMS and healthy controls. However, after cell culture with the autoantigens myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein, frequencies of MBP-reactive and non-proliferating GPR15
Identifiants
pubmed: 30245027
pii: S0896-8411(18)30350-0
doi: 10.1016/j.jaut.2018.09.005
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
GPR15 protein, human
0
Receptors, G-Protein-Coupled
0
Receptors, Peptide
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114-121Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.