The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.
Animals
Carcinogenesis
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
Homeodomain Proteins
/ genetics
Humans
Kidney Neoplasms
/ genetics
Mice, Knockout
Morphogenesis
Nephrons
/ growth & development
Transcription Factors
/ deficiency
Wilms Tumor
/ genetics
Wnt Signaling Pathway
Wnt-5a Protein
/ genetics
IRX3
IRX5
Iroquois
WNT5A
Wilms tumour
differentiation
nephrogenesis
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
06
07
2018
revised:
27
08
2018
accepted:
16
09
2018
pubmed:
25
9
2018
medline:
20
12
2019
entrez:
25
9
2018
Statut:
ppublish
Résumé
Wilms tumour is a paediatric malignancy with features of halted kidney development. Here, we demonstrate that the Iroquois homeobox genes IRX3 and IRX5 are essential for mammalian nephrogenesis and govern the differentiation of Wilms tumour. Knock-out Irx3
Identifiants
pubmed: 30246301
doi: 10.1002/path.5171
pmc: PMC6588170
doi:
Substances chimiques
Homeodomain Proteins
0
IRX3 protein, human
0
IRX5 protein, human
0
Irx3 protein, mouse
0
Irx5 protein, mouse
0
Transcription Factors
0
WNT5A protein, human
0
Wnt-5a Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-98Informations de copyright
© 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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