Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome.
Irritable bowel syndrome
Microbiota
Mucosal immune cells
Short-chain fatty acids
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
21
02
2018
accepted:
18
09
2018
pubmed:
27
9
2018
medline:
19
3
2020
entrez:
26
9
2018
Statut:
ppublish
Résumé
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Probiotics and synbiotics have been shown to improve symptoms of IBS, although mechanisms of action are currently not understood. We investigated the effects of a 4-week oral synbiotic treatment (OMNi-BiOTiC Synbiotics led to an increased microbial diversity in gastric (p = 0.008) and duodenal (p = 0.025) mucosal specimens. FACS analysis of mucosal immune cells showed a treatment-induced reduction of CD4 Our findings indicate that a short-course oral synbiotic trial may influence the human gastrointestinal tract in IBS-D patients on different levels which are region specific.
Identifiants
pubmed: 30251020
doi: 10.1007/s00394-018-1826-7
pii: 10.1007/s00394-018-1826-7
pmc: PMC6768888
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2767-2778Commentaires et corrections
Type : CommentIn
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