Inflammatory markers in women with postpartum depressive symptoms.
cytokines
immune system
inflammation
maternal depression
pregnancy
protein markers
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
03
05
2018
revised:
18
07
2018
accepted:
19
07
2018
pubmed:
27
9
2018
medline:
27
8
2021
entrez:
26
9
2018
Statut:
ppublish
Résumé
Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is not as well studied. The aim of this study was to investigate the alterations in peripheral levels of inflammatory biomarkers in 169 Swedish women with and without depressive symptoms according to the Edinburgh postnatal depression scale or the M.I.N.I neuropsychiatric interview at eight weeks postpartum. Among the 70 markers analyzed with multiplex proximity extension assay, five were significantly elevated in women with postpartum depressive symptoms in the adjusted LASSO logistic regression analysis: Tumor necrosis factor ligand superfamily member (TRANCE) (OR-per 1 SD increase = 1.20), Hepatocyte growth factor (HGF) (OR = 1.17) Interleukin (IL)-18 (OR = 1.06), Fibroblast growth factor 23 (FGF-23) (OR = 1.25), and C-X-C motif chemokine 1 (CXCL1) (OR 1.11). These results indicate that women with PPD have elevated levels of some inflammatory biomarkers. It is, therefore, plausible that PPD is associated with a compromised adaptability of the immune system.
Substances chimiques
Biomarkers
0
Chemokine CXCL1
0
FGF23 protein, human
0
Interleukin-18
0
RANK Ligand
0
Fibroblast Growth Factors
62031-54-3
Hepatocyte Growth Factor
67256-21-7
Fibroblast Growth Factor-23
7Q7P4S7RRE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1309-1321Informations de copyright
© 2018 Wiley Periodicals, Inc.
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