questionsmedicales.fr
Facteurs biologiques
Protéines et peptides de signalisation intercellulaire
Cytokines
Interleukines
Interleukine-18
Interleukine-18 : Questions médicales fréquentes
Diagnostic
5
Interleukine-18
Cytokines
Interleukine-18
Tests de laboratoire
Interleukine-18
Maladies auto-immunes
Interleukine-18
Cytokines
Interleukine-18
Inflammation
Symptômes
5
Interleukine-18
Symptômes inflammatoires
Interleukine-18
Symptômes neurologiques
Interleukine-18
Douleur chronique
Prévention
5
Interleukine-18
Prévention des maladies
Interleukine-18
Nutrition
Interleukine-18
Exercice physique
Interleukine-18
Habitudes de vie
Traitements
5
Interleukine-18
Thérapies ciblées
Interleukine-18
Anticorps monoclonaux
Interleukine-18
Médicaments anti-inflammatoires
Interleukine-18
Immunothérapie
Interleukine-18
Phytothérapie
Complications
5
Interleukine-18
Complications inflammatoires
Interleukine-18
Maladies cardiovasculaires
Interleukine-18
Troubles auto-immuns
Interleukine-18
Infections
Facteurs de risque
5
Interleukine-18
Facteurs de risque
Interleukine-18
Maladies chroniques
Interleukine-18
Mode de vie
Interleukine-18
Prédispositions génétiques
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"@type": "Question",
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"@type": "Question",
"name": "L'IL-18 est-elle liée à des maladies spécifiques ?",
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"@type": "Question",
"name": "L'IL-18 peut-elle être un indicateur de gravité ?",
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"@type": "Question",
"name": "L'IL-18 influence-t-elle la fatigue ?",
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"position": 8,
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{
"@type": "Question",
"name": "L'IL-18 est-elle impliquée dans des douleurs chroniques ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, l'IL-18 peut jouer un rôle dans la douleur chronique liée à l'inflammation."
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{
"@type": "Question",
"name": "Comment l'IL-18 affecte-t-elle l'appétit ?",
"position": 10,
"acceptedAnswer": {
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"text": "L'IL-18 peut influencer l'appétit, souvent diminué lors d'inflammation."
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},
{
"@type": "Question",
"name": "Peut-on prévenir l'augmentation de l'IL-18 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Adopter un mode de vie sain peut aider à réguler les niveaux d'IL-18."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle l'IL-18 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en antioxydants peut réduire l'inflammation et l'IL-18."
}
},
{
"@type": "Question",
"name": "L'exercice physique affecte-t-il l'IL-18 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exercice régulier peut aider à moduler les niveaux d'IL-18 et réduire l'inflammation."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il l'IL-18 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut augmenter les niveaux d'IL-18 et l'inflammation."
}
},
{
"@type": "Question",
"name": "Des habitudes de vie peuvent-elles réduire l'IL-18 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, éviter le tabac et l'alcool peut aider à maintenir des niveaux d'IL-18 bas."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent l'IL-18 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de l'IL-18 sont en développement pour traiter certaines maladies inflammatoires."
}
},
{
"@type": "Question",
"name": "L'IL-18 peut-elle être bloquée ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anticorps monoclonaux peuvent bloquer l'IL-18 pour réduire l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels médicaments influencent l'IL-18 ?",
"position": 18,
"acceptedAnswer": {
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}
},
{
"@type": "Question",
"name": "L'IL-18 est-elle ciblée dans les traitements du cancer ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-18 est explorée comme cible dans certaines immunothérapies contre le cancer."
}
},
{
"@type": "Question",
"name": "Des traitements naturels affectent-ils l'IL-18 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines approches diététiques et phytothérapeutiques peuvent moduler l'IL-18."
}
},
{
"@type": "Question",
"name": "Quelles complications sont liées à l'IL-18 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés d'IL-18 peuvent entraîner des complications inflammatoires graves."
}
},
{
"@type": "Question",
"name": "L'IL-18 est-elle liée à des maladies cardiovasculaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-18 est associée à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Des troubles auto-immuns peuvent-ils résulter de l'IL-18 ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-18 est impliquée dans le développement de troubles auto-immuns."
}
},
{
"@type": "Question",
"name": "L'IL-18 peut-elle aggraver des infections ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés d'IL-18 peuvent exacerber les réponses inflammatoires lors d'infections."
}
},
{
"@type": "Question",
"name": "Y a-t-il un lien entre l'IL-18 et le cancer ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-18 est impliquée dans la progression de certains types de cancer."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent l'IL-18 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité, le tabagisme et le stress sont des facteurs de risque d'augmentation de l'IL-18."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il les niveaux d'IL-18 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les niveaux d'IL-18 tendent à augmenter avec l'âge, surtout chez les personnes malades."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques affectent-elles l'IL-18 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le diabète et l'arthrite augmentent les niveaux d'IL-18."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il l'IL-18 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter l'IL-18."
}
},
{
"@type": "Question",
"name": "Y a-t-il des prédispositions génétiques à l'IL-18 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines variations génétiques peuvent influencer les niveaux d'IL-18."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 01/06/2026
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Division of Rheumatology, Department of Medicine, University Hospitals, Geneva, Switzerland.
Publications dans "Interleukine-18" :
4 publications dans cette catégorie
Affiliations :
Division of Rheumatology, Department of Medicine, University Hospitals, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva, School of Medicine, Geneva, Switzerland. Electronic address: cem.gabay@unige.ch.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Division of Rheumatology, Department of Medicine, University Hospitals, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva, School of Medicine, Geneva, Switzerland.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Departments of Molecular Genetics and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Departments of Molecular Genetics and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Departments of Molecular Genetics and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Nishinomiya, Hyogo, 6638501, Japan.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. halittlemelon@hotmail.com.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. chestshen@gmail.com.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. wenwen816@gmail.com.
Publications dans "Interleukine-18" :
2 publications dans cette catégorie
Affiliations :
Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Division of Rheumatology, Department of Medicine, University Hospitals, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva, School of Medicine, Geneva, Switzerland.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Li Ka Shing Faculty of Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
City University of New York, Graduate School of Public Health and Health Policy, New York, NY, USA.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Li Ka Shing Faculty of Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Li Ka Shing Faculty of Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. koubun@hyo-med.ac.jp.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. nakaken@hyo-med.ac.jp.
Publications dans "Interleukine-18" :
1 publication dans cette catégorie
Affiliations :
Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. tsutsuihiroko3@gmail.com.
Publications dans "Interleukine-18" :
An increased level of interleukin-17A and interleukin-18 in the serum and intestinal mucosa of celiac disease patients reflecting the severity of villous atrophy and inflammation was documented. Thus,...
The study involved 23 participants with serologically confirmed celiac disease (CD) and 23 control subjects. The CD patients had been following a gluten-free diet (GFD) for a minimum of 1 year and had...
The periodontal findings indicated significantly lower values in celiac disease patients adhering to a gluten-free diet compared to control subjects (...
Celiac disease patients on gluten-free diet exhibited better periodontal health compared to control subjects. However, increased levels of salivary IL-17A, IL-18 and IL-1B levels were associated with ...
Lichen planus (LP) is a chronic inflammatory disease with uncertain etiology. Interleukin-18 (IL-18) is an interferon gamma (INFγ) inducing agent. It is a pro-inflammatory cytokine that was found to p...
This study included 50 patients with classic cutaneous lichen planus (CLP) and 50 healthy volunteers serving as controls. Venous blood samples were withdrawn from the study subjects under complete ase...
The mean level of IL-18 was significantly higher in CLP patients (31.63 ± 4.90) compared to control subjects (13.95 ± 6.82). Significantly high levels of IL-18 were found among patients with diabetes,...
IL-18 may play important role in pathogenesis of LP. Elevated IL-18 levels could be part of the pro-inflammatory autoimmune process in LP. The presence of OLP, HCV, diabetes and hypertension is associ...
Extensive observational data suggest a link between celiac disease (CeD) and osteoporosis, but the causality and mediating mechanism remain undetermined. Herein, we performed a Mendelian randomization...
We obtained the summary-level statistics for CeD from a large genome-wide association study (GWAS) comprising 4,533 cases and 10,750 controls of European ancestry. The GWAS data for osteoporosis-relat...
The primary MR analyses demonstrated causal associations between genetically predicted CeD and osteoporosis (odds ratio [OR]: 1.110, 95% confidence interval [CI]: 1.043-1.182,...
The present MR study reveals that CeD is associated with an increased risk of developing osteoporosis, which may be partly mediated by upregulation of interleukin-18....
We assessed the levels of Interleukin-10 (IL-10), Interleukin-12 (IL-12), and Interleukin-18 (IL-18) in the gingival crevicular fluid (GCF) of subjects with advanced periodontitis (SIII-SIV) compared ...
This cross-sectional study involved subjects (n = 60) diagnosed with stage III grade B-C (n = 13) to stage IV grade C (n = 17) periodontitis, and periodontally healthy controls (n = 30). Clinical peri...
There were no significant differences in IL-12 level and IL-18/IL-10 ratio between the healthy and periodontitis groups (p = 0.413, p = 0.636, respectively). The IL-10 and IL-18 levels were significan...
There was a correlation between pocket depth and the presence of IL-18 and a strong association between periodontitis and a high level of IL-18. However, there were no direct correlations among the th...
Understanding the cytokine dynamics in GCF provides valuable insights into their potential clinical implications for periodontal disease diagnosis, risk assessment, and tailored therapeutic interventi...
Altered interleukin (IL)-18 levels are associated with immune-mediated inflammatory diseases (IMIDs), but no studies have investigated their causal relationship. This study aimed to examine the causal...
We performed a two-sample Mendelian randomization (MR) analysis. Genetic variants were selected from genome-wide association study datasets following stringent assessments. We then used these variants...
We found that genetically determined higher circulating IL-18 levels were causally associated with a higher risk for SLE (P...
We have demonstrated that elevated IL-18 levels increase the risk of SLE and IBD but not RA, AS, or psoriasis. The results enhanced our understanding of IL-18 in the pathology of IMIDs....
Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+ T-cell subgroup. Here we apply muti-single cell omic...
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that rises approximately 24-48 h before a diagnosis of acute kidney injury (AKI). Kidney injury molecule-1 (KIM-1) is one of the most promising ea...
Curcumin, a polyphenolic compound derived from the widely used spice...
Interleukin-18 (IL-18) plasma level and latent class analysis (LCA) have separately been shown to predict prognosis and treatment response in acute respiratory distress syndrome (ARDS). IL-18 is a mea...
Statins for acutely injured lungs from sepsis (SAILS) and hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction trial (HARP-2) are two la...
Secondary analysis of two multicenter, randomized controlled clinical trials of ARDS patients....
Six hundred eighty-three patients in SAILS and 511 patients in HARP-2....
None....
We found that 33% of patients in SAILS and HARP-2 were discordant by IL-18 level and LCA class. We further found that IL-18 level was only modestly correlated (0.17-0.47) with cytokines used in the LC...
Plasma IL-18 level provides important additional prognostic information to LCA subphenotypes defined largely by traditional inflammatory biomarkers in two large ARDS cohorts....
Interleukin 18 (IL-18) is a key cytokine involved in the activation of T and NK cells, which are major effector cells in tumor killing. However, recombinant IL-18 showed limited efficacy in clinical t...