Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese.

Genetic Predisposition to Disease Genotype Humans Interleukin-18 / genetics Lung Neoplasms / genetics Polymorphism, Single Nucleotide
Genotype Taiwan interleukin-18 lung cancer polymorphism smoking

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Jul 2022
Historique:
received: 12 02 2022
revised: 11 05 2022
accepted: 10 06 2022
entrez: 5 7 2022
pubmed: 6 7 2022
medline: 7 7 2022
Statut: ppublish

Résumé

The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer. IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology. The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137. IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer.
MATERIALS AND METHODS METHODS
IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology.
RESULTS RESULTS
The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137.
CONCLUSION CONCLUSIONS
IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese.

Identifiants

DOI: 10.21873/anticanres.15825 PMID: 35790262
pubmed: 35790262
pii: 42/7/3381
doi: 10.21873/anticanres.15825
doi:

Substances chimiques

Interleukin-18 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3381-3387

Informations de copyright

Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Meng-Feng Wu (MF)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Division of Chest Surgery, Department of Surgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, R.O.C.

Li-Hsiou Chen (LH)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.

Ning-Yi Hsia (NY)

Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Yi-Cheng Shen (YC)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Te-Chun Shen (TC)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Zhi-Hong Wang (ZH)

Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.

Ya-Chen Yang (YC)

Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.

Yun-Chi Wang (YC)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Wen-Shin Chang (WS)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Te-Chun Hsia (TC)

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.

DA-Tian Bau (DT)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com wenwne816@gmail.com derrick@gmail.com.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.

Chia-Wen Tsai (CW)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

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Classifications MeSH

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questionsmedicales.fr › Phénomènes génétiques › Génotype › Significant Contribution of Interleukin-18...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Significant Contribution of Interleukin-18...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-18 › Significant Contribution of Interleukin-18...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Significant Contribution of Interleukin-18...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Significant Contribution of Interleukin-18...