Interleukin-18 and diabetic nephropathy: A review.
apoptosis
diabetic nephropathy
inflammatory response
interleukin-18
oxidative stress
tumor necrosis factor-α
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
10
07
2018
accepted:
21
08
2018
pubmed:
13
11
2018
medline:
31
3
2020
entrez:
13
11
2018
Statut:
ppublish
Résumé
The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-α, and macrophage chemotactic protein-1; however, the role of IL-18 seems to be more specific than other cytokines in the inflammatory process. IL-18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression/urinary level of IL-18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate. In this review, we have focused on the molecular pathways modulating the relationship between IL-18 and diabetic nephropathy.
Substances chimiques
Anti-Inflammatory Agents
0
Blood Glucose
0
Inflammation Mediators
0
Interleukin-18
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5674-5682Informations de copyright
© 2018 Wiley Periodicals, Inc.