Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children.

Humans Interleukin-18 / metabolism Child Signal Transduction Killer Cells, Natural / immunology fas Receptor / metabolism Monocytes / immunology Systemic Inflammatory Response Syndrome / immunology COVID-19 / immunology Inflammasomes / metabolism SARS-CoV-2 / immunology Adolescent Male Receptors, Antigen, T-Cell, alpha-beta / metabolism Female Child, Preschool Single-Cell Analysis NLR Family, Pyrin Domain-Containing 3 Protein / metabolism CD4-Positive T-Lymphocytes / immunology CD28 Antigens / metabolism Lymphocyte Activation / immunology Receptors, Interleukin-18 / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
18 May 2024
Historique:
received: 31 10 2022
accepted: 10 05 2024
medline: 19 5 2024
pubmed: 19 5 2024
entrez: 18 5 2024
Statut: epublish

Résumé

Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+ T-cell subgroup. Here we apply muti-single cell omics to compare the inflammatory process in children with acute respiratory COVID-19 and those presenting with non SARS-CoV-2 infections in children. Here we show that in Multi-Inflammatory Syndrome in Children (MIS-C), the natural killer cell and monocyte population demonstrate heightened CD95 (Fas) and Interleuking 18 receptor expression. Additionally, TCR Vβ21.3+ CD4+ T-cells exhibit skewed differentiation towards T helper 1, 17 and regulatory T cells, with increased expression of the co-stimulation receptors ICOS, CD28 and interleukin 18 receptor. We observe no functional evidence for NLRP3 inflammasome pathway overactivation, though MIS-C monocytes show elevated active caspase 8. This, coupled with raised IL18 mRNA expression in CD16- NK cells on single cell RNA sequencing analysis, suggests interleukin 18 and CD95 signalling may trigger activation of TCR Vβ21.3+ T-cells in MIS-C, driven by increased IL-18 production from activated monocytes and CD16- Natural Killer cells.

Identifiants

DOI: 10.1038/s41467-024-48699-y PMID: 38762592
pubmed: 38762592
doi: 10.1038/s41467-024-48699-y
pii: 10.1038/s41467-024-48699-y
doi:

Substances chimiques

IL18 protein, human 0
FAS protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4227

Informations de copyright

© 2024. The Author(s).

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Auteurs

Zhenguang Zhang (Z)

Departments of Paediatrics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-8317-3163

Iain R L Kean (IRL)

Departments of Paediatrics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1066-8285

Lisa M Dratva (LM)

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
ORCID: 0000-0002-2873-6787

John A Clark (JA)

Departments of Paediatrics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-6916-9195

Eleni Syrimi (E)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Naeem Khan (N)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Esther Daubney (E)

Paediatric Intensive Care Unit, Addenbrookes Hospital, Cambridge, UK.

Deborah White (D)

Paediatric Intensive Care Unit, Addenbrookes Hospital, Cambridge, UK.

Lauran O'Neill (L)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.

Catherine Chisholm (C)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.

Caroline Payne (C)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.

Sarah Benkenstein (S)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.

Klaudia Kupiec (K)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.
ORCID: 0000-0002-5673-173X

Rachel Galassini (R)

Department of Paediatrics, Imperial College London, London, UK.

Victoria Wright (V)

Department of Paediatrics, Imperial College London, London, UK.
ORCID: 0000-0001-7826-1516

Helen Winmill (H)

Paediatric Intensive Care Unit, Birmingham Children's Hospital, Birmingham, UK.

Ceri Robbins (C)

Paediatric Intensive Care Unit, Birmingham Children's Hospital, Birmingham, UK.

Katherine Brown (K)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.

Padmanabhan Ramnarayan (P)

Department of Paediatrics, Imperial College London, London, UK.

Barnaby Scholefield (B)

Paediatric Intensive Care Unit, Birmingham Children's Hospital, Birmingham, UK.
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
ORCID: 0000-0002-6198-4985

Mark Peters (M)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.
Departments of Paediatrics, University College London, London, UK.

Nigel Klein (N)

Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, UK.
Departments of Paediatrics, University College London, London, UK.
ORCID: 0000-0003-3925-9258

Hugh Montgomery (H)

Critical Care, University College London, London, UK.

Kerstin B Meyer (KB)

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
ORCID: 0000-0001-5906-1498

Sarah A Teichmann (SA)

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Department of Theory of Condensed Matter, Cavendish Laboratory, Department of Physics University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-6294-6366

Clare Bryant (C)

Department of Medicine, University of Cambridge, Cambridge, UK. ceb27@cam.ac.uk.
ORCID: 0000-0002-2924-0038

Graham Taylor (G)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. g.s.taylor@bham.ac.uk.
ORCID: 0000-0002-4807-2797

Nazima Pathan (N)

Departments of Paediatrics, University of Cambridge, Cambridge, UK. np409@cam.ac.uk.
Paediatric Intensive Care Unit, Addenbrookes Hospital, Cambridge, UK. np409@cam.ac.uk.
ORCID: 0000-0002-9447-4252

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-18 › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Antigènes CD95 › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Récepteur lymphocytaire T antigène, alpha-bêta › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CD28 › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Enhanced CD95 and interleukin 18 signalling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-18 › Enhanced CD95 and interleukin 18 signalling...