Interleukin-18 in Health and Disease.
IFN-γ
Inflammation
disease
host defense
innate-type allergy
therapeutic target
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Feb 2019
02 Feb 2019
Historique:
received:
21
12
2018
revised:
28
01
2019
accepted:
29
01
2019
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
22
5
2019
Statut:
epublish
Résumé
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12 is a commitment factor that induces the development of Th1 cells. In contrast, IL-18 is a proinflammatory cytokine that facilitates type 1 responses. However, IL-18 without IL-12 but with IL-2, stimulates NK cells, CD4⁺ NKT cells, and established Th1 cells, to produce IL-3, IL-9, and IL-13. Furthermore, together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Therefore, IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. IL-18 is a member of the IL-1 family of cytokines. IL-18 demonstrates a unique function by binding to a specific receptor expressed on various types of cells. In this review article, we will focus on the unique features of IL-18 in health and disease in experimental animals and humans.
Identifiants
pubmed: 30717382
pii: ijms20030649
doi: 10.3390/ijms20030649
pmc: PMC6387150
pii:
doi:
Substances chimiques
Interleukin-18
0
Interleukin-33
0
Receptors, Interleukin-18
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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